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Tbio
DNAL4
Dynein light chain 4, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity (By similarity). This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216068
  • ENSP00000216068
  • ENSG00000100246

Symbol
  • MRMV3
  • PIG27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
small molecule perturbation
0.7
tissue sample
0.68
tissue
0.55
cellular component
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
DYNLL1
Tbio
Novelty:  0.00397334
p_int:  0.999993886
p_ni:  0.000006114
Score:  0.594
Data Source:  BioPlex,STRINGDB
STOX2
Tbio
Novelty:  0.48153003
p_int:  0.999989854
p_ni:  0.000003033
p_wrong:  0.000007114
Data Source:  BioPlex
DYNLL2
Tbio
Novelty:  0.11209457
p_int:  0.999986543
p_ni:  0.000013457
p_wrong:  1e-9
Score:  0.615
Data Source:  BioPlex,STRINGDB
STOX1
Tbio
Novelty:  0.03270001
p_int:  0.999899187
p_ni:  1.8e-8
p_wrong:  0.000100795
Data Source:  BioPlex
IPP
Tbio
Novelty:  0.12841634
p_int:  0.999111887
p_ni:  0.000879947
p_wrong:  0.000008166
Data Source:  BioPlex
CCS
Tbio
Family:  Enzyme
Novelty:  0.01379006
p_int:  0.998165239
p_ni:  0.001834309
p_wrong:  4.52e-7
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.995280595
p_ni:  0.004719405
Data Source:  BioPlex
CAMK2B
Tchem
Family:  Kinase
Novelty:  0.00793595
p_int:  0.994639542
p_ni:  0.005360458
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.987869004
p_ni:  0.012130996
Data Source:  BioPlex
CAP1
Tbio
Family:  Enzyme
Novelty:  0.0333464
p_int:  0.975534803
p_ni:  0.024465197
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Retrograde neurotrophin signalling (R-HSA-177504)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Retrograde neurotrophin signalling
Reactome
Signal Transduction
Reactome
Signaling by NTRK1 (TRKA)
Reactome
Signaling by NTRKs
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Retrograde neurotrophin signalling
Signal Transduction
Signaling by NTRK1 (TRKA)
Signaling by NTRKs
Signaling by Receptor Tyrosine Kinases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
3
3
94.2
serum gamma-glutamyl transferase measurement
1
1
1
82.5
heel bone mineral density
2
1
2
77
1
1
0
1.2
64.9
mathematical ability
3
2
3
64.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
94.2
serum gamma-glutamyl transferase measurement
1
82.5
heel bone mineral density
2
77
0
1.2
64.9
mathematical ability
3
64.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal light chain 4
VGNC:8858
100611328
Macaque
dynein axonemal light chain 4
702019
Mouse
MGI:1859217
54152
Rat
RGD:1309099
300078
Dog
dynein axonemal light chain 4
VGNC:40022
474505
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal light chain 4
Macaque
dynein axonemal light chain 4
Mouse
Rat
Dog
dynein axonemal light chain 4
Publication Statistics
PubMed Score 5.50
PubMed score by year
PubTator Score 2.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title