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Tbio
DNAJC7
DnaJ homolog subfamily C member 7

Protein Summary
Description
Acts as co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity). This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316603
  • ENSP00000313311
  • ENSG00000168259
  • ENST00000426588
  • ENSP00000394327
  • ENST00000457167
  • ENSP00000406463

Symbol
  • TPR2
  • TTC2
  • DJ11
  • DJC7
  • TPR2
  • TTC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.96
disease perturbation
0.9
transcription factor binding site profile
0.88
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.95   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 215   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.95   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
EML5
Tdark
Novelty:  0.29826509
p_int:  0.999998134
p_ni:  0.000001866
Score:  0.154
Data Source:  BioPlex,STRINGDB
VPS13B
Tbio
Novelty:  0.02154769
p_int:  0.999994013
p_ni:  0.000005987
Data Source:  BioPlex
BBS10
Tbio
Novelty:  0.03343798
p_int:  0.999988044
p_ni:  0.000011906
p_wrong:  5e-8
Score:  0.237
Data Source:  BioPlex,STRINGDB
KIAA0100
Tbio
Novelty:  0.10510857
p_int:  0.999984856
p_ni:  0.000015144
Score:  0.201
Data Source:  BioPlex,STRINGDB
NPHP1
Tbio
Novelty:  0.01113034
p_int:  0.999979188
p_ni:  0.000020218
p_wrong:  5.93e-7
Data Source:  BioPlex
FANCB
Tbio
Novelty:  0.00268111
p_int:  0.999949015
p_ni:  0.000050984
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
URGCP
Tbio
Novelty:  0.05171079
p_int:  0.999582947
p_ni:  0.000017371
p_wrong:  0.000399683
Score:  0.199
Data Source:  BioPlex,STRINGDB
WDR41
Tbio
Novelty:  0.20400077
p_int:  0.99948209
p_ni:  0.000475309
p_wrong:  0.000042601
Data Source:  BioPlex
GREB1
Tbio
Novelty:  0.01644388
p_int:  0.997539863
p_ni:  0.002446575
p_wrong:  0.000013561
Score:  0.188
Data Source:  BioPlex,STRINGDB
C5orf34
Tdark
Novelty:  1.01063928
p_int:  0.994410052
p_ni:  0.005589948
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
3
3
85
3
2
3
65.7
mean reticulocyte volume
1
1
1
65.6
reticulocyte measurement
1
1
1
44.2
mean corpuscular volume
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
3
85
3
65.7
mean reticulocyte volume
1
65.6
reticulocyte measurement
1
44.2
mean corpuscular volume
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C7
VGNC:9264
454674
Macaque
DnaJ heat shock protein family (Hsp40) member C7
708729
Mouse
MGI:1928373
56354
Rat
RGD:1303226
303536
Dog
DnaJ heat shock protein family (Hsp40) member C7
480519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C7
Macaque
DnaJ heat shock protein family (Hsp40) member C7
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C7
Publication Statistics
PubMed Score 43.95
PubMed score by year
PubTator Score 19.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title