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Tdark
DNAJC30
DnaJ homolog subfamily C member 30, mitochondrial

Protein Summary
Description
Mitochondrial protein enriched in neurons that acts as a regulator of mitochondrial respiration (By similarity). Associates with the ATP synthase complex and facilitates ATP synthesis (By similarity). This intronless gene encodes a member of the DNAJ molecular chaperone homology domain-containing protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395176
  • ENSP00000378605
  • ENSG00000176410

Symbol
  • WBSCR18
  • WBSCR18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
transcription factor binding site profile
0.59
cell line
0.56
tissue sample
0.56
cell type or tissue
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (39)
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.999947668
p_ni:  0.00005048
p_wrong:  0.000001852
Data Source:  BioPlex
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.999945461
p_ni:  0.000054538
p_wrong:  1e-9
Score:  0.652
Data Source:  BioPlex,STRINGDB
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.999858047
p_ni:  0.000141943
p_wrong:  1.1e-8
Score:  0.686
Data Source:  BioPlex,STRINGDB
SLC9A6
Tbio
Family:  Transporter
Novelty:  0.01410234
p_int:  0.999839517
p_ni:  0.000159216
p_wrong:  0.000001267
Score:  0.196
Data Source:  BioPlex,STRINGDB
TMED2
Tbio
Novelty:  0.03731104
p_int:  0.99954503
p_ni:  0.000454957
p_wrong:  1.3e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.997846479
p_ni:  0.002120823
p_wrong:  0.000032698
Data Source:  BioPlex
CHRNB1
Tclin
Family:  IC
Novelty:  0.04777051
p_int:  0.996628278
p_ni:  0.003226537
p_wrong:  0.000145185
Data Source:  BioPlex
ECEL1
Tbio
Family:  Enzyme
Novelty:  0.01488521
p_int:  0.996088359
p_ni:  0.003792228
p_wrong:  0.000119413
Data Source:  BioPlex
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.994294758
p_ni:  0.00564689
p_wrong:  0.000058352
Score:  0.527
Data Source:  BioPlex,STRINGDB
NDUFB3
Tclin
Family:  Enzyme
Novelty:  0.13020753
p_int:  0.99412455
p_ni:  0.005866038
p_wrong:  0.000009413
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
13
19
35
10.5
99.9
serum gamma-glutamyl transferase measurement
4
5
4
4.5
98.4
high density lipoprotein cholesterol measurement
8
9
15
98.3
testosterone measurement
4
4
4
94.7
BMI-adjusted waist-hip ratio
7
8
13
93.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
35
10.5
99.9
serum gamma-glutamyl transferase measurement
4
4.5
98.4
high density lipoprotein cholesterol measurement
15
98.3
testosterone measurement
4
94.7
BMI-adjusted waist-hip ratio
13
93.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C30
716630
Mouse
MGI:1913364
66114
Rat
RGD:1595783
368190
Dog
DnaJ heat shock protein family (Hsp40) member C30
VGNC:53533
489805
Horse
DnaJ heat shock protein family (Hsp40) member C30
VGNC:51124
100146721
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C30
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C30
Horse
DnaJ heat shock protein family (Hsp40) member C30
Publication Statistics
PubMed Score 3.98
PubMed score by year
PubTator Score 0.64
PubTator score by year
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Related Publications
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PMID
Year
Title