DNAJC3
DnaJ homolog subfamily C member 3
Protein Summary
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
- ENST00000602402
- ENSP00000473631
- ENSG00000102580
- P58IPK
- PRKRI
- P58
- HP58
- ACPHD
- ERdj6
- PRKRI
- P58IPK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
protein domain | 0.85 | ||
histone modification site profile | 0.84 | ||
transcription factor perturbation | 0.84 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.96 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 150 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.96 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 150 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (325)
DEDD
Novelty: 0.01549618
p_int: 0.998993534
p_ni: 0.000926596
p_wrong: 0.00007987
Data Source: BioPlex
DNAJB9
Novelty: 0.00536296
p_int: 0.990383163
p_ni: 0.009606345
p_wrong: 0.000010492
Score: 0.431
Data Source: BioPlex,STRINGDB
ADGRV1
Family: GPCR
Novelty: 0.01398129
p_int: 0.981137239
p_ni: 0.018862761
Data Source: BioPlex
MGAT5
Family: Enzyme
Novelty: 0.00707747
p_int: 0.938407736
p_ni: 0.061588717
p_wrong: 0.000003547
Data Source: BioPlex
LAMB2
Novelty: 0.07966931
p_int: 0.771681295
p_ni: 0.228318705
Score: 0.902
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (16)
KEGG (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | IRE1alpha activates chaperones | ||||
Reactome | Immune System | ||||
Reactome | Infectious disease | ||||
Reactome | Influenza Infection | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
IRE1alpha activates chaperones | ||||
Immune System | ||||
Infectious disease | ||||
Influenza Infection | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (5)
Components (10)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urate measurement | 1 | 1 | 1 | 31.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urate measurement | 1 | 31.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DnaJ heat shock protein family (Hsp40) member C3 | VGNC:7284 | 736800 | |||||
Macaque | DnaJ heat shock protein family (Hsp40) member C3 | 695757 | ||||||
Mouse | MGI:107373 | 100037258 | ||||||
Rat | RGD:708518 | 63880 | ||||||
Dog | DnaJ heat shock protein family (Hsp40) member C3 | 476966 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DnaJ heat shock protein family (Hsp40) member C3 | |||||
Macaque | DnaJ heat shock protein family (Hsp40) member C3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | DnaJ heat shock protein family (Hsp40) member C3 | |||||
Publication Statistics
PubMed Score 53.96
PubMed score by year
PubTator Score 23.12
PubTator score by year
Related Publications
Text Mined References (31)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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