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Tbio
DNAJC3
DnaJ homolog subfamily C member 3

Protein Summary
Description
Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000602402
  • ENSP00000473631
  • ENSG00000102580

Symbol
  • P58IPK
  • PRKRI
  • P58
  • HP58
  • ACPHD
  • ERdj6
  • PRKRI
  • P58IPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
protein domain
0.85
histone modification site profile
0.84
transcription factor perturbation
0.84
disease perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.96   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.96   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
TENM3
Tbio
Novelty:  0.0251948
p_int:  0.999993925
p_ni:  0.000006064
p_wrong:  1e-8
Data Source:  BioPlex
DEDD
Tbio
Novelty:  0.01549618
p_int:  0.998993534
p_ni:  0.000926596
p_wrong:  0.00007987
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.990383163
p_ni:  0.009606345
p_wrong:  0.000010492
Score:  0.431
Data Source:  BioPlex,STRINGDB
ADGRV1
Tbio
Family:  GPCR
Novelty:  0.01398129
p_int:  0.981137239
p_ni:  0.018862761
Data Source:  BioPlex
MGAT5
Tbio
Family:  Enzyme
Novelty:  0.00707747
p_int:  0.938407736
p_ni:  0.061588717
p_wrong:  0.000003547
Data Source:  BioPlex
OLFML2B
Tbio
Novelty:  0.19222155
p_int:  0.828377176
p_ni:  0.171622824
Data Source:  BioPlex
LAMB2
Tbio
Novelty:  0.07966931
p_int:  0.771681295
p_ni:  0.228318705
Score:  0.902
Data Source:  BioPlex,STRINGDB
PDIA6
Tchem
Family:  Enzyme
Novelty:  0.01692178
Score:  0.997
Data Source:  STRINGDB
HSP90B1
Tchem
Novelty:  0.00135881
Score:  0.995
Data Source:  STRINGDB
P4HB
Tchem
Family:  Enzyme
Novelty:  0.00107905
Score:  0.986
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
IRE1alpha activates chaperones
Reactome
Immune System
Reactome
Infectious disease
Reactome
Influenza Infection
Name
Explore in Pharos
Explore in Source
Disease
IRE1alpha activates chaperones
Immune System
Infectious disease
Influenza Infection
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C3
VGNC:7284
736800
Macaque
DnaJ heat shock protein family (Hsp40) member C3
695757
Mouse
MGI:107373
100037258
Rat
RGD:708518
63880
Dog
DnaJ heat shock protein family (Hsp40) member C3
476966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C3
Macaque
DnaJ heat shock protein family (Hsp40) member C3
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C3
Publication Statistics
PubMed Score 53.96
PubMed score by year
PubTator Score 23.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title