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Tbio
DNAJC19
Mitochondrial import inner membrane translocase subunit TIM14

Protein Summary
Description
Probable component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). The protein encoded by this gene is thought to be part of a complex involved in the ATP-dependent transport of transit peptide-containing proteins from the inner cell membrane to the mitochondrial matrix. Defects in this gene are a cause of 3-methylglutaconic aciduria type 5 (MGA5), also known as dilated cardiomyopathy with ataxia (DCMA). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1, 2, 6, 10, 14 and 19. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382564
  • ENSP00000372005
  • ENSG00000205981
  • ENST00000479269
  • ENSP00000419191
  • ENST00000491873
  • ENSP00000420767

Symbol
  • TIM14
  • TIMM14
  • PAM18
  • TIM14
  • TIMM14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
histone modification site profile
0.87
cellular component
0.72
tissue sample
0.7
tissue
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.61   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 137   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.61   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (150)
ABTB2
Tdark
Novelty:  0.45729157
p_int:  0.980015967
p_ni:  0.019563502
p_wrong:  0.000420531
Data Source:  BioPlex
SPACA1
Tbio
Novelty:  0.07415851
p_int:  0.973593252
p_ni:  0.026406748
Data Source:  BioPlex
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.942079666
p_ni:  0.057904526
p_wrong:  0.000015808
Data Source:  BioPlex
SLC15A1
Tchem
Family:  Transporter
Novelty:  0.00149723
p_int:  0.938358517
p_ni:  0.061641455
p_wrong:  2.8e-8
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.937003582
p_ni:  0.062996415
p_wrong:  2e-9
Data Source:  BioPlex
P2RX4
Tchem
Family:  IC
Novelty:  0.00242958
p_int:  0.927452553
p_ni:  0.072547436
p_wrong:  1.1e-8
Data Source:  BioPlex
SLC2A12
Tbio
Family:  Transporter
Novelty:  0.01455533
p_int:  0.901313441
p_ni:  0.09868654
p_wrong:  1.9e-8
Score:  0.184
Data Source:  BioPlex,STRINGDB
LPAR4
Tchem
Family:  GPCR
Novelty:  0.02200758
p_int:  0.900563337
p_ni:  0.095999273
p_wrong:  0.00343739
Data Source:  BioPlex
RANBP6
Tdark
Novelty:  0.75714796
p_int:  0.898279368
p_ni:  0.101720625
p_wrong:  7e-9
Data Source:  BioPlex
DUOXA2
Tbio
Family:  Enzyme
Novelty:  0.02873436
p_int:  0.889550494
p_ni:  0.110410655
p_wrong:  0.000038851
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
5
3
2
1.1
88.1
educational attainment
1
3
3
81.9
self reported educational attainment
2
2
2
76.1
antisocial behaviour measurement
1
1
1
46.5
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
schizophrenia
2
1.1
88.1
educational attainment
3
81.9
self reported educational attainment
2
76.1
antisocial behaviour measurement
1
46.5
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C19
VGNC:6201
460868
Macaque
DnaJ heat shock protein family (Hsp40) member C19
710082
Mouse
MGI:1914963
67713
Dog
DnaJ heat shock protein family (Hsp40) member C19
VGNC:53460
100856039
Horse
DnaJ heat shock protein family (Hsp40) member C19
100058535
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C19
Macaque
DnaJ heat shock protein family (Hsp40) member C19
Mouse
Dog
DnaJ heat shock protein family (Hsp40) member C19
Horse
DnaJ heat shock protein family (Hsp40) member C19
Publication Statistics
PubMed Score 47.61
PubMed score by year
PubTator Score 15.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title