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Tbio
DNAJC15
DnaJ homolog subfamily C member 15

Protein Summary
Description
Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP (By similarity). Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379221
  • ENSP00000368523
  • ENSG00000120675

Symbol
  • DNAJD1
  • MCJ
  • HSD18
  • DNAJD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.81
disease perturbation
0.79
gene perturbation
0.76
transcription factor binding site profile
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.24   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.24   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
PAM16
Tbio
Family:  Enzyme
Novelty:  0.04932685
Score:  0.954
Data Source:  STRINGDB
TIMM17B
Tdark
Family:  Enzyme
Novelty:  0.03556998
Score:  0.763
Data Source:  STRINGDB
TIMM17A
Tbio
Family:  Enzyme
Novelty:  0.02095904
Score:  0.745
Data Source:  STRINGDB
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
Score:  0.719
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.711
Data Source:  STRINGDB
DNAJC25
Tdark
Novelty:  1.55044803
Score:  0.701
Data Source:  STRINGDB
DNAJC1
Tbio
Family:  TF
Novelty:  0.07277849
Score:  0.676
Data Source:  STRINGDB
IQGAP3
Tbio
Family:  Enzyme
Novelty:  0.05874747
Score:  0.673
Data Source:  STRINGDB
DNAJC9
Tbio
Novelty:  0.25748073
Score:  0.666
Data Source:  STRINGDB
DNAJA3
Tbio
Novelty:  0.02196177
Score:  0.661
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (36)
Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Nuclear Receptors Meta-Pathway
WikiPathways
Toll-like Receptor Signaling Pathway
Name
Explore in Pharos
Explore in Source
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Nuclear Receptors Meta-Pathway
Toll-like Receptor Signaling Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
65.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C15
700339
Mouse
MGI:1913398
66148
Rat
RGD:1307154
290370
Dog
DnaJ heat shock protein family (Hsp40) member C15
476930
Horse
DnaJ heat shock protein family (Hsp40) member C15 [Source:HGNC Symbol;Acc:HGNC:20325]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member C15
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C15
Horse
DnaJ heat shock protein family (Hsp40) member C15 [Source:HGNC Symbol;Acc:HGNC:20325]
Publication Statistics
PubMed Score 22.24
PubMed score by year
PubTator Score 17.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title