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Tbio
DNAJC13
DnaJ homolog subfamily C member 13

Protein Summary
Description
Involved in membrane trafficking through early endosomes, such as the early endosome to recycling endosome transport implicated in the recycling of transferrin and the early endosome to late endosome transport implicated in degradation of EGF and EGFR (PubMed:18256511, PubMed:18307993). Involved in the regulation of endosomal membrane tubulation and regulates th dynamics of SNX1 on the endosomal membrane; via association with WASHC2 may link the WASH complex to the retromer SNX-BAR subcomplex (PubMed:24643499). This gene encodes a member of the Dnaj protein family whose members act as co-chaperones of a partner heat-shock protein by binding to the latter and stimulating ATP hydrolysis. The encoded protein associates with the heat-shock protein Hsc70 and plays a role in clathrin-mediated endocytosis. It may also be involved in post-endocytic transport mechanisms via its associations with other proteins, including the sorting nexin SNX1. Mutations in this gene are associated with Parkins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260818
  • ENSP00000260818
  • ENSG00000138246

Symbol
  • KIAA0678
  • RME8
  • RME8
  • PARK21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
histone modification site profile
0.83
transcription factor perturbation
0.74
protein domain
0.73
cell line
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.39   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 37   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.39   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999999117
p_ni:  8.83e-7
Data Source:  BioPlex
LIPG
Tchem
Family:  Enzyme
Novelty:  0.00412129
p_int:  0.999998649
p_ni:  0.000001351
Data Source:  BioPlex
TMEM9B
Tdark
Novelty:  0.56628366
p_int:  0.999998619
p_ni:  0.000001381
Data Source:  BioPlex
SCAMP1
Tbio
Novelty:  0.03293648
p_int:  0.999997331
p_ni:  0.000002669
Score:  0.226
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.999996711
p_ni:  0.000003289
Data Source:  BioPlex
FCN1
Tbio
Novelty:  0.01037775
p_int:  0.999911552
p_ni:  0.000088448
Score:  0.207
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.999854637
p_ni:  0.000145363
Score:  0.745
Data Source:  BioPlex,STRINGDB
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.999679483
p_ni:  0.000320517
Score:  0.906
Data Source:  BioPlex,STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
p_int:  0.999641572
p_ni:  0.000358428
Score:  0.437
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999569084
p_ni:  0.000430916
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
5
7
94.2
red blood cell distribution width
4
3
4
93.1
apolipoprotein B measurement
2
3
3
87
CCL21 measurement
1
2
2
85.4
total cholesterol measurement
3
5
5
82.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
94.2
red blood cell distribution width
4
93.1
apolipoprotein B measurement
3
87
CCL21 measurement
2
85.4
total cholesterol measurement
5
82.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C13
VGNC:6200
460703
Macaque
DnaJ heat shock protein family (Hsp40) member C13
717741
Mouse
MGI:2676368
235567
Rat
RGD:1308046
363127
Dog
DnaJ heat shock protein family (Hsp40) member C13
VGNC:52873
485663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C13
Macaque
DnaJ heat shock protein family (Hsp40) member C13
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C13
Publication Statistics
PubMed Score 36.39
PubMed score by year
PubTator Score 18.73
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title