Tbio DNAJC12 DnaJ homolog subfamily C member 12

Protein Summary

Description

This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UKB3
• Q5JVQ1
• Q9UKB2

Gene Name

• DNAJC12

Ensembl ID

• ENST00000225171
• ENSP00000225171
• ENSG00000108176
• ENST00000339758
• ENSP00000343575

Symbol

• JDP1
• JDP1
• HPANBH4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.91
transcription factor perturbation	0.84
gene perturbation	0.83
cell type or tissue	0.77
PubMedID	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.36   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.36   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (83)

Explore Interacting Targets

1 – 10 of 83

• See Interactions on String-DB

TH

Tclin

Family:  Enzyme

Novelty:  0.00025719

p_int:  0.999989971

p_ni:  0.000010029

Score:  0.186

Data Source:  BioPlex,STRINGDB

TPH1

Tclin

Family:  Enzyme

Novelty:  0.00098637

p_int:  0.999988505

p_ni:  0.000011495

Score:  0.324

Data Source:  BioPlex,STRINGDB

ANTXR1

Tbio

Novelty:  0.00508081

p_int:  0.999622161

p_ni:  0.000377838

Data Source:  BioPlex

ERI2

Tbio

Family:  Enzyme

Novelty:  0.10111379

p_int:  0.998030005

p_ni:  0.001969995

Score:  0.345

Data Source:  BioPlex,STRINGDB

TPH2

Tchem

Family:  Enzyme

Novelty:  0.00265377

p_int:  0.997770269

p_ni:  0.00222857

p_wrong:  0.000001162

Score:  0.388

Data Source:  BioPlex,STRINGDB

LIPH

Tbio

Family:  Enzyme

Novelty:  0.00961658

p_int:  0.993456651

p_ni:  0.006543306

p_wrong:  4.4e-8

Data Source:  BioPlex

ITLN1

Tbio

Novelty:  0.00299735

p_int:  0.989092322

p_ni:  0.010907676

p_wrong:  2e-9

Score:  0.19

Data Source:  BioPlex,STRINGDB

PLPPR2

Tdark

Family:  Enzyme

Novelty:  1.03318406

p_int:  0.989049221

p_ni:  0.010950779

Data Source:  BioPlex

ARL4C

Tbio

Family:  Enzyme

Novelty:  0.04764628

p_int:  0.988934752

p_ni:  0.011065247

p_wrong:  1e-9

Data Source:  BioPlex

PRMT6

Tchem

Family:  Epigenetic

Novelty:  0.01734208

p_int:  0.978428465

p_ni:  0.021571532

p_wrong:  3e-9

Score:  0.169

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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GO Term	Evidence	Assigned by
cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (8)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	2	2		73.4
mean platelet volume	EFO_0004584	2	2	2		64.8
leukocyte count	EFO_0004308	1	1	1		56.8
alkaline phosphatase measurement	EFO_0004533	1	1	1		45.7
sex hormone-binding globulin measurement	EFO_0004696	2	1	2		28

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		73.4
mean platelet volume	EFO_0004584	2		64.8
leukocyte count	EFO_0004308	1		56.8
alkaline phosphatase measurement	EFO_0004533	1		45.7
sex hormone-binding globulin measurement	EFO_0004696	2		28

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Alternative splicing
Chaperone
Complete proteome
Cytoplasm
Disease mutation
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
atrial fibrillation
glucose measurement
leukocyte count
mean platelet volume
myeloid white cell count
neutrophil count
sex hormone-binding globulin measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	DnaJ heat shock protein family (Hsp40) member C12	VGNC:12305	466287
Macaque	DnaJ heat shock protein family (Hsp40) member C12		695795
Mouse	DnaJ heat shock protein family (Hsp40) member C12	MGI:1353428	30045
Rat	DnaJ heat shock protein family (Hsp40) member C12	RGD:1591898	619393
Dog	DnaJ heat shock protein family (Hsp40) member C12		479224

Species	Name	OMA	EggNOG	Inparanoid
Chimp	DnaJ heat shock protein family (Hsp40) member C12
Macaque	DnaJ heat shock protein family (Hsp40) member C12
Mouse	DnaJ heat shock protein family (Hsp40) member C12
Rat	DnaJ heat shock protein family (Hsp40) member C12
Dog	DnaJ heat shock protein family (Hsp40) member C12

Publication Statistics

PubMed Score 25.36

PubMed score by year

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PubTator Score 13.29

PubTator score by year

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Related Publications

Text Mined References (15)

GeneRif Annotations (9)

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10

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PMID	Year	Title