Tbio DNAJC11 DnaJ homolog subfamily C member 11

Protein Summary

Description

Isoform 1: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex.

Uniprot Accession IDs

• Q9NVH1
• Q4VWF5
• Q5VZN0
• Q6PK20
• Q6PK70
• Q8NDM2
• Q96CL7

Gene Name

• DNAJC11

Ensembl ID

• ENST00000294401
• ENSP00000294401
• ENSG00000007923
• ENST00000377577
• ENSP00000366800

Symbol

• dJ126A5.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.91
disease perturbation	0.9
histone modification site profile	0.76
tissue sample	0.72
transcription factor	0.7

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.65   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.65   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0