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Tbio
DNAJC10
DnaJ homolog subfamily C member 10

Protein Summary
Description
Endoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress. This gene encodes an endoplasmic reticulum co-chaperone which is part of the endoplasmic reticulum-associated degradation complex involved in recognizing and degrading misfolded proteins. The encoded protein reduces incorrect disulfide bonds in misfolded glycoproteins. Alternatively spliced transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264065
  • ENSP00000264065
  • ENSG00000077232
  • ENST00000537515
  • ENSP00000441560
  • ENST00000616986
  • ENSP00000479930

Symbol
  • ERDJ5
  • JPDI
  • MTHr
  • ERdj5
  • PDIA19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
interacting protein
0.96
histone modification site profile
0.92
kinase perturbation
0.81
disease perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.55   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.55   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
p_int:  0.999999566
p_ni:  4.32e-7
p_wrong:  2e-9
Score:  0.223
Data Source:  BioPlex,STRINGDB
MTMR4
Tbio
Family:  Enzyme
Novelty:  0.09166984
p_int:  0.999968314
p_ni:  0.00003167
p_wrong:  1.6e-8
Data Source:  BioPlex
FBLN5
Tbio
Novelty:  0.00599598
p_int:  0.999919563
p_ni:  0.000080436
p_wrong:  1e-9
Data Source:  BioPlex
TRAPPC13
Tdark
Novelty:  0.4415
p_int:  0.999269978
p_ni:  0.000730022
Score:  0.187
Data Source:  BioPlex,STRINGDB
GRN
Tbio
Novelty:  0.00096395
p_int:  0.998649903
p_ni:  0.001350097
Score:  0.25
Data Source:  BioPlex,STRINGDB
LTBP4
Tbio
Novelty:  0.02008164
p_int:  0.996742458
p_ni:  0.003257542
Data Source:  BioPlex
AKAP9
Tbio
Family:  Enzyme
Novelty:  0.0106532
p_int:  0.990879977
p_ni:  0.009120023
Score:  0.46
Data Source:  BioPlex,STRINGDB
ITPRID2
Tbio
Novelty:  0.07923791
p_int:  0.989479576
p_ni:  0.010520424
Data Source:  BioPlex
WAPL
Tbio
Novelty:  0.01598061
p_int:  0.988381736
p_ni:  0.011618264
Score:  0.201
Data Source:  BioPlex,STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
p_int:  0.982284194
p_ni:  0.017715798
p_wrong:  8e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
1
3
70.9
self reported educational attainment
1
2
2
36.5
1
1
0
5.8
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
70.9
self reported educational attainment
2
36.5
0
5.8
1.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C10
VGNC:6364
459799
Macaque
DnaJ heat shock protein family (Hsp40) member C10
705787
Mouse
MGI:1914111
66861
Rat
RGD:1307813
295690
Dog
DnaJ heat shock protein family (Hsp40) member C10
VGNC:53092
478826
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C10
Macaque
DnaJ heat shock protein family (Hsp40) member C10
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C10
Publication Statistics
PubMed Score 45.55
PubMed score by year
PubTator Score 19.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title