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Tbio
DNAJC1
DnaJ homolog subfamily C member 1

Protein Summary
Description
May modulate protein synthesis. The membrane protein encoded by this gene is a DNAJ-like heat shock protein that binds the molecular chaperone BiP. In addition, the encoded protein contains two SANT domains that have been shown to bind serpin alpha1-antichymotrypsin and inter-alpha trypsin inhibitor heavy chain 4. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376980
  • ENSP00000366179
  • ENSG00000136770

Symbol
  • HTJ1
  • HTJ1
  • MTJ1
  • ERdj1
  • DNAJL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor perturbation
0.84
transcription factor binding site profile
0.83
disease perturbation
0.79
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.8   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.8   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
CLEC2D
Tbio
Novelty:  0.02501194
p_int:  0.999986518
p_ni:  0.000013481
Data Source:  BioPlex
HEATR3
Tbio
Novelty:  0.08367436
p_int:  0.997666127
p_ni:  0.00233387
p_wrong:  2e-9
Data Source:  BioPlex
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
p_int:  0.990198705
p_ni:  0.009800657
p_wrong:  6.38e-7
Score:  0.288
Data Source:  BioPlex,STRINGDB
DDX60
Tbio
Family:  Enzyme
Novelty:  0.09487565
p_int:  0.988721088
p_ni:  0.010574327
p_wrong:  0.000704585
Data Source:  BioPlex
MINDY2
Tbio
Novelty:  0.46783751
p_int:  0.987214928
p_ni:  0.012785012
p_wrong:  6e-8
Score:  0.201
Data Source:  BioPlex,STRINGDB
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.985255747
p_ni:  0.014740309
p_wrong:  0.000003944
Score:  0.16
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.98320403
p_ni:  0.016795968
p_wrong:  2e-9
Data Source:  BioPlex
TSPAN31
Tbio
Novelty:  0.13580467
p_int:  0.978236779
p_ni:  0.020422896
p_wrong:  0.001340326
Data Source:  BioPlex
P10321
Tbio
Novelty:  0.00698601
p_int:  0.966035935
p_ni:  0.033964065
Data Source:  BioPlex
C15orf41
Tbio
Novelty:  0.11812699
p_int:  0.959158759
p_ni:  0.040839601
p_wrong:  0.00000164
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
1
1.2
93.2
visceral adipose tissue measurement
1
1
1
76.3
diet measurement
2
2
2
69.8
educational attainment
1
2
2
62.1
body weight
1
1
1
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.2
93.2
visceral adipose tissue measurement
1
76.3
diet measurement
2
69.8
educational attainment
2
62.1
body weight
1
55.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C1
VGNC:1632
450344
Macaque
DnaJ heat shock protein family (Hsp40) member C1
704151
Mouse
MGI:103268
13418
Rat
RGD:2322144
100360412
Dog
DnaJ heat shock protein family (Hsp40) member C1
VGNC:52128
607587
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C1
Macaque
DnaJ heat shock protein family (Hsp40) member C1
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C1
Publication Statistics
PubMed Score 15.80
PubMed score by year
PubTator Score 8.67
PubTator score by year
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Related Publications
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PMID
Year
Title