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Tbio
DNAJB9
DnaJ homolog subfamily B member 9

Protein Summary
Description
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). This gene is a member of the J protein family. J proteins function in many cellular processes by regulating the ATPase activity of 70 kDa heat shock proteins. This gene is a member of the type 2 subgroup of DnaJ proteins. The encoded protein is locali ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249356
  • ENSP00000249356
  • ENSG00000128590

Symbol
  • MDG1
  • MDG1
  • ERdj4
  • MDG-1
  • MST049
  • MSTP049
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
small molecule perturbation
0.94
histone modification site profile
0.92
transcription factor binding site profile
0.91
microRNA
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.9   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.9   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (121)
ECEL1
Tbio
Family:  Enzyme
Novelty:  0.01488521
p_int:  0.99989276
p_ni:  0.00010724
Score:  0.152
Data Source:  BioPlex,STRINGDB
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.998390524
p_ni:  0.001609476
Data Source:  BioPlex
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.998341695
p_ni:  0.001658305
Score:  0.641
Data Source:  BioPlex,STRINGDB
DUOXA2
Tbio
Family:  Enzyme
Novelty:  0.02873436
p_int:  0.998104133
p_ni:  0.001895865
p_wrong:  1e-9
Data Source:  BioPlex
FAM136A
Tdark
Novelty:  0.4050275
p_int:  0.995805398
p_ni:  0.004194602
Data Source:  BioPlex
TNFSF14
Tbio
Novelty:  0.01370893
p_int:  0.993745273
p_ni:  0.006254391
p_wrong:  3.37e-7
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.993415869
p_ni:  0.006584095
p_wrong:  3.5e-8
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.992049702
p_ni:  0.007950298
Data Source:  BioPlex
DNAJC3
Tbio
Novelty:  0.02129782
p_int:  0.990383163
p_ni:  0.009606345
p_wrong:  0.000010492
Score:  0.431
Data Source:  BioPlex,STRINGDB
GRIA3
Tclin
Family:  IC
Novelty:  0.00584546
p_int:  0.987711075
p_ni:  0.012288925
Score:  0.158
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
1
1
4.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
comparative body size at age 10, self-reported
1
4.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B9
VGNC:14004
744984
Mouse
MGI:1351618
27362
Rat
RGD:3070
24908
Dog
DnaJ heat shock protein family (Hsp40) member B9
VGNC:53539
475286
Horse
DnaJ heat shock protein family (Hsp40) member B9
100055586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B9
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B9
Horse
DnaJ heat shock protein family (Hsp40) member B9
Publication Statistics
PubMed Score 205.90
PubMed score by year
PubTator Score 40.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title