Tbio DNAJB8 DnaJ homolog subfamily B member 8

Protein Summary

Description

Efficient suppressor of aggregation and toxicity of disease-associated polyglutamine proteins. The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• Q8NHS0
• B3KWV7

Gene Name

• DNAJB8

Ensembl ID

• ENST00000319153
• ENSP00000316053
• ENSG00000179407
• ENST00000469083
• ENSP00000417418

Symbol

• DJ6
• CT156

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.71
tissue sample	0.71
cell line	0.52
tissue	0.51
gene perturbation	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.07   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.07   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0