Tbio DNAJB7 DnaJ homolog subfamily B member 7

Protein Summary

Description

Probably acts as a co-chaperone. The protein encoded by this intronless gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain.[provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• Q7Z6W7
• Q2M220
• Q5H904
• Q8WYJ7

Gene Name

• DNAJB7

Ensembl ID

• ENST00000307221
• ENSP00000307197
• ENSG00000172404

Symbol

• HSC3
• DJ5
• HSC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
tissue sample	0.66
microRNA	0.61
tissue	0.53
cell type or tissue	0.37

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.14   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.14   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0