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Tbio
DNAJB5
DnaJ homolog subfamily B member 5

Protein Summary
Description
This gene encodes a member of the DNAJ heat shock protein 40 family of co-chaperone proteins. The encoded protein contains an N-terminal DNAJ domain and a C-terminal substrate binding domain but lacks the cysteine-rich domain found in other DNAJ family members. In mice, a multi-protein complex containing this protein, thioredoxin 1, and histone deacetylase 4, serves as a master negative regulator of cardiac hypertrophy. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312316
  • ENSP00000312517
  • ENSG00000137094
  • ENST00000453597
  • ENSP00000404079
  • ENST00000454002
  • ENSP00000413684
  • ENST00000545841
  • ENSP00000441999

Symbol
  • HSC40
  • Hsc40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.81
transcription factor perturbation
0.61
small molecule perturbation
0.59
protein domain
0.58
histone modification site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.999995515
p_ni:  0.000004482
p_wrong:  3e-9
Score:  0.234
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999972186
p_ni:  0.000027814
Data Source:  BioPlex
DNAJB4
Tbio
Novelty:  0.03467352
p_int:  0.999960919
p_ni:  0.000039081
Score:  0.824
Data Source:  BioPlex,STRINGDB
P2RX6
Tchem
Family:  IC
Novelty:  0.02091945
p_int:  0.999586442
p_ni:  0.000413557
p_wrong:  1e-9
Score:  0.866
Data Source:  BioPlex,STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
p_int:  0.999571284
p_ni:  0.000428715
p_wrong:  2e-9
Score:  0.72
Data Source:  BioPlex,STRINGDB
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.998477281
p_ni:  0.001522719
Data Source:  BioPlex
KHDC1
Tbio
Novelty:  0.13778027
p_int:  0.996589301
p_ni:  0.003410684
p_wrong:  1.5e-8
Data Source:  BioPlex
ACVR1C
Tbio
Family:  Kinase
Novelty:  0.01675672
p_int:  0.99394147
p_ni:  0.006020145
p_wrong:  0.000038385
Data Source:  BioPlex
ARHGEF10
Tbio
Novelty:  0.04928387
p_int:  0.993169385
p_ni:  0.006830613
p_wrong:  2e-9
Score:  0.236
Data Source:  BioPlex,STRINGDB
TBC1D22A
Tbio
Novelty:  0.46374046
p_int:  0.990192766
p_ni:  0.009639748
p_wrong:  0.000167486
Score:  0.536
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
57.8
mean platelet volume
1
1
1
53.7
mean corpuscular volume
1
1
1
33
mean reticulocyte volume
1
1
1
29.8
monocyte count
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
57.8
mean platelet volume
1
53.7
mean corpuscular volume
1
33
mean reticulocyte volume
1
29.8
monocyte count
1
12.6
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B5
VGNC:4708
746375
Macaque
DnaJ heat shock protein family (Hsp40) member B5
699081
Mouse
MGI:1930018
56323
Rat
RGD:1307453
313811
Dog
DnaJ heat shock protein family (Hsp40) member B5
VGNC:51709
474753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B5
Macaque
DnaJ heat shock protein family (Hsp40) member B5
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B5
Publication Statistics
PubMed Score 4.19
PubMed score by year
PubTator Score 1.97
PubTator score by year
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Related Publications
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PMID
Year
Title