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Tbio
DNAJB4
DnaJ homolog subfamily B member 4

Protein Summary
Description
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370763
  • ENSP00000359799
  • ENSG00000162616

Symbol
  • DNAJW
  • HLJ1
  • DjB4
  • HLJ1
  • DNAJW
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
virus perturbation
0.85
small molecule perturbation
0.79
transcription factor
0.78
microRNA
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.66   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 236   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.66   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 236   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (104)
DNAJB1
Tbio
Novelty:  0.00139956
p_int:  0.999999996
p_ni:  4e-9
Score:  0.868
Data Source:  BioPlex,STRINGDB
SYNM
Tbio
Novelty:  0.01167838
p_int:  0.999999879
p_ni:  1.19e-7
p_wrong:  2e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
DNAJB5
Tbio
Novelty:  0.20703358
p_int:  0.999960919
p_ni:  0.000039081
Score:  0.824
Data Source:  BioPlex,STRINGDB
C3orf38
Tdark
Novelty:  2.10467478
p_int:  0.999713446
p_ni:  0.000286546
p_wrong:  8e-9
Score:  0.527
Data Source:  BioPlex,STRINGDB
KCNC4
Tclin
Family:  IC
Novelty:  0.01215128
p_int:  0.994955599
p_ni:  0.005044401
Score:  0.318
Data Source:  BioPlex,STRINGDB
TTLL12
Tbio
Family:  Enzyme
Novelty:  0.12652318
p_int:  0.992796758
p_ni:  0.007203242
Score:  0.602
Data Source:  BioPlex,STRINGDB
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.95758036
p_ni:  0.04241964
Data Source:  BioPlex
ABHD15
Tdark
Family:  Enzyme
Novelty:  1.53507944
p_int:  0.954364531
p_ni:  0.045635469
Score:  0.167
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.948561229
p_ni:  0.051438771
Data Source:  BioPlex
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
p_int:  0.925709429
p_ni:  0.074290571
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
80.3
body mass index
4
2
9
78.7
diastolic blood pressure
1
1
1
73.5
self reported educational attainment
3
3
3
68.3
waist circumference
2
2
2
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
80.3
body mass index
9
78.7
diastolic blood pressure
1
73.5
self reported educational attainment
3
68.3
waist circumference
2
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B4
VGNC:6780
100608554
Mouse
MGI:1914285
67035
Rat
RGD:1305826
295549
Dog
DnaJ heat shock protein family (Hsp40) member B4
VGNC:49082
479982
Horse
DnaJ heat shock protein family (Hsp40) member B4
VGNC:50828
100053123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B4
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B4
Horse
DnaJ heat shock protein family (Hsp40) member B4
Publication Statistics
PubMed Score 31.66
PubMed score by year
PubTator Score 17.27
PubTator score by year
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Related Publications
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PMID
Year
Title