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Tbio
DNAJB11
DnaJ homolog subfamily B member 11

Protein Summary
Description
As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins (PubMed:10827079, PubMed:15525676, PubMed:29706351). Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed (PubMed:15525676). May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity (PubMed:10827079). It is necessary for maturation and correct trafficking of PKD1 (PubMed:29706351). This gene encodes a soluble glycoprotein of the endoplasmic reticulum (ER) lumen that functions as a co-chaperone of binding immunoglobulin protein, a 70 kilodalton heat shock protein chaperone required for the proper folding and assembly of proteins in the ER. The encoded protein contains a highly conserved J domain of about 70 amino acids with a characteristic His-Pro-Asp (HPD) motif and may regulate the activity of binding immuno ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265028
  • ENSP00000265028
  • ENSG00000090520
  • ENST00000439351
  • ENSP00000414398

Symbol
  • EDJ
  • ERJ3
  • HDJ9
  • DJ9
  • EDJ
  • Dj-9
  • ERj3
  • PKD6
  • ABBP2
  • ERdj3
  • ERj3p
  • ABBP-2
  • UNQ537
  • PRO1080
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.91
kinase perturbation
0.91
transcription factor perturbation
0.88
virus perturbation
0.88
phenotype
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.3   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.3   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
ROCK2
Tclin
Family:  Kinase
Novelty:  0.00242311
p_int:  0.999998186
p_ni:  0.000001814
Score:  0.254
Data Source:  BioPlex,STRINGDB
KCTD21
Tbio
Novelty:  1.05252269
p_int:  0.999995113
p_ni:  0.000004887
Score:  0.198
Data Source:  BioPlex,STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.999883354
p_ni:  0.000116646
Data Source:  BioPlex
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999471405
p_ni:  0.000528592
p_wrong:  3e-9
Data Source:  BioPlex
SIMC1
Tbio
Novelty:  0.39770049
p_int:  0.998080022
p_ni:  0.001919978
Score:  0.193
Data Source:  BioPlex,STRINGDB
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.997483276
p_ni:  0.002516724
Score:  0.923
Data Source:  BioPlex,STRINGDB
TUBA4A
Tchem
Novelty:  0.00820546
p_int:  0.987010129
p_ni:  0.012989871
Score:  0.176
Data Source:  BioPlex,STRINGDB
NUBPL
Tbio
Novelty:  0.01059986
p_int:  0.964817152
p_ni:  0.035182848
Score:  0.403
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.919265718
p_ni:  0.080734282
Score:  0.994
Data Source:  BioPlex,STRINGDB
BORA
Tbio
Novelty:  0.0374925
p_int:  0.919030326
p_ni:  0.080774153
p_wrong:  0.000195521
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
3
3
77.2
intraocular pressure measurement
1
1
1
61.4
partial thromboplastin time
1
1
1
50.6
electrocardiography
1
1
5
21.5
neutrophil count
1
1
1
6.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
3
77.2
intraocular pressure measurement
1
61.4
partial thromboplastin time
1
50.6
electrocardiography
5
21.5
neutrophil count
1
6.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B11
VGNC:6198
460911
Mouse
MGI:1915088
67838
Rat
RGD:1307373
360734
Dog
DnaJ heat shock protein family (Hsp40) member B11
VGNC:53459
478664
Horse
DnaJ heat shock protein family (Hsp40) member B11
100059460
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member B11
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B11
Horse
DnaJ heat shock protein family (Hsp40) member B11
Publication Statistics
PubMed Score 42.30
PubMed score by year
PubTator Score 23.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title