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Tbio
DNAJA3
DnaJ homolog subfamily A member 3, mitochondrial

Protein Summary
Description
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. This gene encodes a member of the DNAJ/Hsp40 protein family. DNAJ/Hsp40 proteins stimulate the ATPase activity of Hsp70 chaperones and play critical roles in protein folding, degradation, and multimeric complex assembly. The encoded protein is localized to mitochondria and mediates several cellular processes including proliferation, survival and apoptotic signal transduction. The encoded protein also plays a critical role in tumor suppression through interactions with oncogenic prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262375
  • ENSP00000262375
  • ENSG00000103423
  • ENST00000355296
  • ENSP00000347445
  • ENST00000431375
  • ENSP00000393970
  • ENST00000612103
  • ENSP00000477570
  • ENSG00000276726
  • ENST00000614397
  • ENSP00000479815

Symbol
  • HCA57
  • TID1
  • TID1
  • HCA57
  • hTID-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
0.98
biological process
0.94
molecular function
0.93
transcription factor binding site profile
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.85   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.85   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0