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Tbio
DNAH14
Dynein heavy chain 14, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366848
  • ENSP00000355813
  • ENSG00000185842
  • ENST00000366850
  • ENSP00000355815
  • ENST00000400952
  • ENSP00000383737
  • ENST00000430092
  • ENSP00000414402
  • ENST00000439375
  • ENSP00000392061
  • ENST00000445597
  • ENSP00000409472

Symbol
  • C1orf67
  • HL18
  • HL-18
  • C1orf67
  • Dnahc14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
protein domain
0.73
cell line
0.65
cellular component
0.65
histone modification site profile
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0