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Tbio
DNAAF4
Dynein assembly factor 4, axonemal

Protein Summary
Description
Axonemal dynein assembly factor required for ciliary motility. Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity. This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321149
  • ENSP00000323275
  • ENSG00000256061
  • ENST00000348518
  • ENSP00000299561
  • ENST00000448430
  • ENSP00000403412
  • ENST00000457155
  • ENSP00000402640

Symbol
  • DYX1C1
  • EKN1
  • RD
  • DYX1
  • EKN1
  • DYXC1
  • CILD25
  • DYX1C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.96   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 252   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.96   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 252   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999994722
p_wrong:  0.000005277
Score:  0.219
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.996886237
p_ni:  0.003113763
Score:  0.205
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
Score:  0.937
Data Source:  STRINGDB
KIAA0319
Tbio
Novelty:  0.01425914
Score:  0.923
Data Source:  STRINGDB
DCDC2
Tbio
Novelty:  0.00395729
Score:  0.909
Data Source:  STRINGDB
ZMYND10
Tbio
Novelty:  0.05524895
Score:  0.832
Data Source:  STRINGDB
DNAAF3
Tbio
Novelty:  0.06768631
Score:  0.826
Data Source:  STRINGDB
LRRC6
Tbio
Novelty:  0.10994386
Score:  0.813
Data Source:  STRINGDB
GCFC2
Tbio
Novelty:  0.04245608
Score:  0.794
Data Source:  STRINGDB
ROBO1
Tbio
Novelty:  0.00494884
Score:  0.789
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal assembly factor 4
453458
Macaque
dynein axonemal assembly factor 4
100429795
Mouse
MGI:1914935
67685
Rat
RGD:1549760
363096
Dog
dynein axonemal assembly factor 4
VGNC:40009
487567
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal assembly factor 4
Macaque
dynein axonemal assembly factor 4
Mouse
Rat
Dog
dynein axonemal assembly factor 4
Publication Statistics
PubMed Score 64.96
PubMed score by year
PubTator Score 42.41
PubTator score by year
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Related Publications
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PMID
Year
Title