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Tbio
DNAAF3
Dynein assembly factor 3, axonemal

Protein Summary
Description
Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia. The protein encoded by this gene is required for the assembly of axonemal inner and outer dynein arms and plays a role in assembling dynein complexes for transport into cilia. Defects in this gene are a cause of primary ciliary dyskinesia type 2 (CILD2). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391720
  • ENSP00000375600
  • ENSG00000167646
  • ENST00000455045
  • ENSP00000394343
  • ENST00000524407
  • ENSP00000432046
  • ENST00000527223
  • ENSP00000436975
  • ENST00000528412
  • ENSP00000433826
  • ENST00000534214
  • ENSP00000433247

Symbol
  • C19orf51
  • PCD
  • DAB1
  • PF22
  • CILD2
  • C19orf51
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.73
tissue sample
0.73
cell type or tissue
0.63
transcription factor binding site profile
0.57
tissue
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
SP6
Tbio
Family:  TF
Novelty:  0.00201789
p_int:  0.999995856
p_ni:  2.68e-7
p_wrong:  0.000003875
Score:  0.532
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
Score:  0.926
Data Source:  STRINGDB
DAW1
Tdark
Novelty:  0.08712536
Score:  0.871
Data Source:  STRINGDB
DNAAF5
Tbio
Novelty:  0.27921814
Score:  0.831
Data Source:  STRINGDB
ZMYND10
Tbio
Novelty:  0.05524895
Score:  0.827
Data Source:  STRINGDB
DNAAF4
Tbio
Novelty:  0.01730685
Score:  0.826
Data Source:  STRINGDB
LRRC6
Tbio
Novelty:  0.10994386
Score:  0.812
Data Source:  STRINGDB
FAM187A
Tdark
Novelty:  0.07857649
Score:  0.805
Data Source:  STRINGDB
CCDC103
Tbio
Novelty:  0.07857649
Score:  0.805
Data Source:  STRINGDB
SPAG1
Tbio
Novelty:  0.01839474
Score:  0.797
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
5
5
84.9
platelet crit
2
4
5
81.2
mean corpuscular volume
1
3
3
78.2
phosphatidylethanolamine measurement
9
8
15
73.7
monocyte count
2
2
2
69.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
84.9
platelet crit
5
81.2
mean corpuscular volume
3
78.2
phosphatidylethanolamine measurement
15
73.7
monocyte count
2
69.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3588207
436022
Rat
RGD:2323487
100359753
Dog
dynein axonemal assembly factor 3
VGNC:53690
484300
Cow
dynein axonemal assembly factor 3
104968460
Fruitfly
FBgn0034352
37125
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
dynein axonemal assembly factor 3
Cow
dynein axonemal assembly factor 3
Fruitfly
Publication Statistics
PubMed Score 19.94
PubMed score by year
PubTator Score 8.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title