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Tbio
DNAAF2
Protein kintoun

Protein Summary
Description
Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in this gene have been associated with primary ciliary dyskinesia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000298292
  • ENSP00000298292
  • ENSG00000165506
  • ENST00000406043
  • ENSP00000384862

Symbol
  • C14orf104
  • KTU
  • KTU
  • PF13
  • CILD10
  • C14orf104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
transcription factor
0.67
cell line
0.63
histone modification site profile
0.58
small molecule perturbation
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.6   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.6   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
LMO1
Tbio
Novelty:  0.01670419
p_int:  0.999999993
p_ni:  6e-9
Data Source:  BioPlex
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
p_int:  0.999999973
p_ni:  1.9e-8
p_wrong:  8e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ALS2
Tbio
Novelty:  0.0072324
p_int:  0.999999315
p_ni:  6.84e-7
Score:  0.201
Data Source:  BioPlex,STRINGDB
HIST1H2BL
Tdark
Novelty:  0.64500134
p_int:  0.999998416
p_ni:  0.000001545
p_wrong:  3.9e-8
Data Source:  BioPlex
STX1B
Tbio
Novelty:  0.01171833
p_int:  0.999995651
p_ni:  0.000004349
Data Source:  BioPlex
GRIA2
Tclin
Family:  IC
Novelty:  0.00141257
p_int:  0.999994823
p_ni:  0.000005175
p_wrong:  2e-9
Data Source:  BioPlex
VSNL1
Tbio
Novelty:  0.01221371
p_int:  0.999993485
p_ni:  0.000006512
p_wrong:  3e-9
Data Source:  BioPlex
L1CAM
Tbio
Novelty:  0.00307041
p_int:  0.999989238
p_ni:  0.000010747
p_wrong:  1.5e-8
Data Source:  BioPlex
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
p_int:  0.999987326
p_ni:  0.000012659
p_wrong:  1.5e-8
Data Source:  BioPlex
HPCAL4
Tdark
Novelty:  0.26673582
p_int:  0.999981112
p_ni:  0.000018877
p_wrong:  1.2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal assembly factor 2
VGNC:9047
452887
Macaque
dynein axonemal assembly factor 2
719026
Mouse
MGI:1923566
109065
Rat
RGD:1310311
362746
Cow
dynein axonemal assembly factor 2
VGNC:28119
534465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal assembly factor 2
Macaque
dynein axonemal assembly factor 2
Mouse
Rat
Cow
dynein axonemal assembly factor 2
Publication Statistics
PubMed Score 81.60
PubMed score by year
PubTator Score 9.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title