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Tbio
DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

Protein Summary
Description
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Accordin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358410
  • ENSP00000351185
  • ENSG00000138346
  • ENST00000399179
  • ENSP00000382132
  • ENST00000399180
  • ENSP00000382133

Symbol
  • DNA2L
  • KIAA0083
  • DNA2L
  • hDNA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
histone modification site profile
0.87
biological process
0.77
cellular component
0.77
cell type or tissue
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.68   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 493.68   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (253)
CDR2
Tbio
Novelty:  0.00141419
p_int:  0.999501598
p_ni:  0.000498402
Score:  0.192
Data Source:  BioPlex,STRINGDB
SMG7
Tbio
Novelty:  0.03394393
p_int:  0.998966973
p_ni:  0.001032952
p_wrong:  7.5e-8
Score:  0.422
Data Source:  BioPlex,STRINGDB
NOB1
Tbio
Novelty:  0.01209681
p_int:  0.997638542
p_ni:  0.002361175
p_wrong:  2.83e-7
Score:  0.22
Data Source:  BioPlex,STRINGDB
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.987713751
p_ni:  0.012286249
Data Source:  BioPlex
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
p_int:  0.97911296
p_ni:  0.020886642
p_wrong:  3.98e-7
Score:  0.502
Data Source:  BioPlex,STRINGDB
MMS19
Tbio
Novelty:  0.01978769
p_int:  0.953974559
p_ni:  0.046025441
Score:  0.91
Data Source:  BioPlex,STRINGDB
TARSL2
Tbio
Family:  Enzyme
Novelty:  0.02406282
p_int:  0.931873347
p_ni:  0.068126649
p_wrong:  5e-9
Score:  0.155
Data Source:  BioPlex,STRINGDB
BORA
Tbio
Novelty:  0.0374925
p_int:  0.93187279
p_ni:  0.06812721
Score:  0.402
Data Source:  BioPlex,STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
p_int:  0.929316648
p_ni:  0.009643911
p_wrong:  0.061039441
Score:  0.184
Data Source:  BioPlex,STRINGDB
MSTO1
Tbio
Novelty:  0.05914188
p_int:  0.91742186
p_ni:  0.082575911
p_wrong:  0.00000223
Score:  0.316
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
Chromosome Maintenance
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Chromosome Maintenance
DNA Double-Strand Break Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (34)
Find Similar Targets
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
78.7
BMI-adjusted hip circumference
1
5
5
70.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
78.7
BMI-adjusted hip circumference
5
70.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA replication helicase/nuclease 2
VGNC:5446
450496
Mouse
MGI:2443732
327762
Dog
DNA replication helicase/nuclease 2
VGNC:40008
489015
Horse
DNA replication helicase/nuclease 2
VGNC:17233
100072606
Cow
DNA replication helicase/nuclease 2
VGNC:28118
540969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA replication helicase/nuclease 2
Mouse
Dog
DNA replication helicase/nuclease 2
Horse
DNA replication helicase/nuclease 2
Cow
DNA replication helicase/nuclease 2
Publication Statistics
PubMed Score 493.68
PubMed score by year
PubTator Score 198.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title