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Tbio
DMXL2
DmX-like protein 2

Protein Summary
Description
May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed:11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity). This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251076
  • ENSP00000251076
  • ENSG00000104093
  • ENST00000449909
  • ENSP00000400855
  • ENST00000543779
  • ENSP00000441858

Symbol
  • KIAA0856
  • RC3
  • PEPNS
  • DFNA71
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
cell line
0.75
cellular component
0.66
tissue sample
0.66
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.6   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.6   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
ROGDI
Tbio
Novelty:  0.077277
p_int:  0.999999994
p_ni:  6e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.999896055
p_ni:  0.000103945
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.999485528
p_ni:  0.000514439
p_wrong:  3.3e-8
Data Source:  BioPlex
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.998520188
p_ni:  0.001479812
Data Source:  BioPlex
RP2
Tbio
Novelty:  0.12345247
p_int:  0.995632676
p_ni:  0.004367324
Score:  0.184
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.994951315
p_ni:  0.005048684
p_wrong:  1e-9
Score:  0.266
Data Source:  BioPlex,STRINGDB
GLUL
Tchem
Family:  Enzyme
Novelty:  0.00086054
p_int:  0.99102745
p_ni:  0.008972295
p_wrong:  2.54e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.979247285
p_ni:  0.020752715
Data Source:  BioPlex
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.962600519
p_ni:  0.037399481
Data Source:  BioPlex
DEF8
Tbio
Novelty:  0.21146806
p_int:  0.849163267
p_ni:  0.15082433
p_wrong:  0.000012403
Score:  0.159
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
2
5
89.4
intelligence
2
4
2
6.6
79.9
blood protein measurement
1
2
2
79
heel bone mineral density
1
1
1
75.6
C-reactive protein measurement
2
2
2
73.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
89.4
intelligence
2
6.6
79.9
blood protein measurement
2
79
heel bone mineral density
1
75.6
C-reactive protein measurement
2
73.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Dmx like 2
VGNC:6579
453436
Macaque
Dmx like 2
693954
Mouse
MGI:2444630
235380
Rat
RGD:1586163
315676
Dog
Dmx like 2
VGNC:40007
478306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Dmx like 2
Macaque
Dmx like 2
Mouse
Rat
Dog
Dmx like 2
Publication Statistics
PubMed Score 23.60
PubMed score by year
PubTator Score 6.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title