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Tbio
DMWD
Dystrophia myotonica WD repeat-containing protein

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270223
  • ENSP00000270223
  • ENSG00000185800

Symbol
  • DM9
  • DMRN9
  • DMR-N9
  • gene59
  • D19S593E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
histone modification site profile
0.77
transcription factor
0.72
disease perturbation
0.62
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.54   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.54   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
USP46
Tbio
Family:  Enzyme
Novelty:  0.04594593
p_int:  0.99999949
p_ni:  5.1e-7
Score:  0.74
Data Source:  BioPlex,STRINGDB
WDR6
Tbio
Novelty:  0.20146637
p_int:  0.999351946
p_ni:  0.000648054
Score:  0.217
Data Source:  BioPlex,STRINGDB
DHX33
Tbio
Family:  Enzyme
Novelty:  0.07473852
p_int:  0.998338961
p_ni:  0.001661025
p_wrong:  1.4e-8
Data Source:  BioPlex
TKT
Tchem
Family:  Enzyme
Novelty:  0.00333936
p_int:  0.995793834
p_ni:  0.004206166
Data Source:  BioPlex
ARHGAP25
Tbio
Family:  Enzyme
Novelty:  0.14944305
p_int:  0.993464634
p_ni:  0.006535364
p_wrong:  1e-9
Score:  0.158
Data Source:  BioPlex,STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
p_int:  0.99301929
p_ni:  0.00698071
Score:  0.432
Data Source:  BioPlex,STRINGDB
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.988207711
p_ni:  0.011792287
p_wrong:  1e-9
Data Source:  BioPlex
SHARPIN
Tbio
Novelty:  0.0197352
p_int:  0.987322777
p_ni:  0.012674744
p_wrong:  0.00000248
Data Source:  BioPlex
CHIC1
Tdark
Novelty:  0.06718561
p_int:  0.978583288
p_ni:  0.021416663
p_wrong:  4.9e-8
Data Source:  BioPlex
FERD3L
Tbio
Family:  TF
Novelty:  0.06797434
p_int:  0.977078793
p_ni:  0.022921187
p_wrong:  2.1e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
4
5
97.1
total cholesterol measurement
1
3
3
94.5
apolipoprotein B measurement
2
2
3
94.1
eosinophil count
2
4
4
91.7
testosterone measurement
3
4
4
90.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
5
97.1
total cholesterol measurement
3
94.5
apolipoprotein B measurement
3
94.1
eosinophil count
4
91.7
testosterone measurement
4
90.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DM1 locus, WD repeat containing
VGNC:14843
456140
Mouse
MGI:94907
13401
Rat
RGD:1594179
680252
Horse
DM1 locus, WD repeat containing [Source:HGNC Symbol;Acc:HGNC:2936]
Cow
DM1 locus, WD repeat containing
790091
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DM1 locus, WD repeat containing
Mouse
Rat
Horse
DM1 locus, WD repeat containing [Source:HGNC Symbol;Acc:HGNC:2936]
Cow
DM1 locus, WD repeat containing
Publication Statistics
PubMed Score 22.54
PubMed score by year
PubTator Score 5.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title