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Tbio
DMTN
Dematin

Protein Summary
Description
Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motilit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265800
  • ENSP00000265800
  • ENSG00000158856
  • ENST00000358242
  • ENSP00000350977
  • ENST00000381470
  • ENSP00000370879
  • ENST00000415253
  • ENSP00000401291
  • ENST00000432128
  • ENSP00000416111
  • ENST00000443491
  • ENSP00000397904
  • ENST00000517305
  • ENSP00000430609
  • ENST00000517600
  • ENSP00000430618
  • ENST00000519907
  • ENSP00000429377
  • ENST00000523266
  • ENSP00000427866
  • ENST00000523782
  • ENSP00000429234

Symbol
  • DMT
  • EPB49
  • DMT
  • EPB49
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor
0.79
PubMedID
0.77
small molecule perturbation
0.77
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.01   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 266.01   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.998144676
p_ni:  0.001855324
Score:  0.163
Data Source:  BioPlex,STRINGDB
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.972183699
p_ni:  0.027816301
Score:  0.227
Data Source:  BioPlex,STRINGDB
UBR1
Tbio
Family:  Enzyme
Novelty:  0.00998888
p_int:  0.963665453
p_ni:  0.036334547
Score:  0.183
Data Source:  BioPlex,STRINGDB
YWHAG
Tchem
Novelty:  0.00845572
p_int:  0.936288914
p_ni:  0.063711086
Score:  0.21
Data Source:  BioPlex,STRINGDB
YWHAB
Tbio
Novelty:  0.00614093
p_int:  0.81323411
p_ni:  0.18676589
Score:  0.196
Data Source:  BioPlex,STRINGDB
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.78791858
p_ni:  0.21208142
Score:  0.226
Data Source:  BioPlex,STRINGDB
ADD2
Tbio
Family:  Enzyme
Novelty:  0.01097975
Score:  0.979
Data Source:  Reactome,STRINGDB
ADD3
Tbio
Family:  Enzyme
Novelty:  0.02164464
Score:  0.961
Data Source:  Reactome,STRINGDB
ADD1
Tbio
Family:  Enzyme
Novelty:  0.0040587
Score:  0.957
Data Source:  Reactome,STRINGDB
EPB42
Tbio
Family:  Enzyme
Novelty:  0.06393286
Score:  0.876
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
3
3
94.3
low density lipoprotein cholesterol measurement
5
5
5
81.8
serum alanine aminotransferase measurement
2
2
1
7
78.1
mean corpuscular hemoglobin concentration
1
1
1
77.4
apolipoprotein B measurement
2
2
2
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
94.3
low density lipoprotein cholesterol measurement
5
81.8
serum alanine aminotransferase measurement
1
7
78.1
mean corpuscular hemoglobin concentration
1
77.4
apolipoprotein B measurement
2
76.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dematin actin binding protein
VGNC:889
741796
Macaque
dematin actin binding protein
706762
Mouse
MGI:99670
13829
Dog
dematin actin binding protein
VGNC:40005
486132
Horse
dematin actin binding protein
VGNC:17230
100056495
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dematin actin binding protein
Macaque
dematin actin binding protein
Mouse
Dog
dematin actin binding protein
Horse
dematin actin binding protein
Publication Statistics
PubMed Score 266.01
PubMed score by year
PubTator Score 36.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title