Protein Summary
May act as a soluble regulator of keratinocyte differentiation. This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
- ENST00000339686
- ENSP00000342012
- ENSG00000161249
- ENST00000408915
- ENSP00000386225
- ENST00000414866
- ENSP00000392222
- ENST00000418261
- ENSP00000414743
- ENST00000419602
- ENSP00000391036
- ENST00000424570
- ENSP00000388404
- ENST00000429837
- ENSP00000405503
- ENST00000447113
- ENSP00000394908
- ENST00000451297
- ENSP00000409513
- ENST00000472252
- ENSP00000473341
- ENST00000492341
- ENSP00000474419
- UNQ729
- ZD52F10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
PubMedID | 0.71 | ||
transcription factor perturbation | 0.68 | ||
transcription factor | 0.61 | ||
cell type or tissue | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.93 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.93 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0