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Tbio
DMKN
Dermokine

Protein Summary
Description
May act as a soluble regulator of keratinocyte differentiation. This gene is upregulated in inflammatory diseases, and it was first observed as expressed in the differentiated layers of skin. The most interesting aspect of this gene is the differential use of promoters and terminators to generate isoforms with unique cellular distributions and domain components. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339686
  • ENSP00000342012
  • ENSG00000161249
  • ENST00000408915
  • ENSP00000386225
  • ENST00000414866
  • ENSP00000392222
  • ENST00000418261
  • ENSP00000414743
  • ENST00000419602
  • ENSP00000391036
  • ENST00000424570
  • ENSP00000388404
  • ENST00000429837
  • ENSP00000405503
  • ENST00000447113
  • ENSP00000394908
  • ENST00000451297
  • ENSP00000409513
  • ENST00000472252
  • ENSP00000473341
  • ENST00000492341
  • ENSP00000474419

Symbol
  • UNQ729
  • ZD52F10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.71
transcription factor perturbation
0.68
transcription factor
0.61
cell type or tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.43   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.43   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (10)
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.999491475
p_ni:  0.000042301
p_wrong:  0.000466223
Score:  0.214
Data Source:  BioPlex,STRINGDB
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.999179702
p_ni:  0.000818558
p_wrong:  0.00000174
Score:  0.188
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.994736674
p_ni:  0.005261506
p_wrong:  0.000001821
Score:  0.179
Data Source:  BioPlex,STRINGDB
SSH2
Tbio
Family:  Enzyme
Novelty:  0.05112042
p_int:  0.784454353
p_ni:  0.000335904
p_wrong:  0.215209743
Data Source:  BioPlex
BAG6
Tbio
Novelty:  0.0035578
Score:  0.777
Data Source:  STRINGDB
SBSN
Tbio
Novelty:  0.05105712
Score:  0.63
Data Source:  STRINGDB
KRTDAP
Tdark
Novelty:  0.12206865
Score:  0.593
Data Source:  STRINGDB
MYH14
Tchem
Novelty:  0.00874871
Score:  0.531
Data Source:  STRINGDB
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
Score:  0.471
Data Source:  STRINGDB
PRELID2
Tdark
Novelty:  0.38276284
Score:  0.42
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
3
3
86.2
hemoglobin measurement
3
3
3
76.8
serum albumin measurement
1
1
1
69.8
red blood cell distribution width
2
2
2
67.1
serum alanine aminotransferase measurement
2
1
1
6.9
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
86.2
hemoglobin measurement
3
76.8
serum albumin measurement
1
69.8
red blood cell distribution width
2
67.1
serum alanine aminotransferase measurement
1
6.9
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dermokine
718709
Mouse
MGI:1920962
73712
Rat
RGD:1561521
361548
Dog
dermokine
VGNC:40000
476484
Cow
dermokine
VGNC:28107
618159
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dermokine
Mouse
Rat
Dog
dermokine
Cow
dermokine
Publication Statistics
PubMed Score 12.43
PubMed score by year
PubTator Score 2.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title