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Tbio
DMBT1
Deleted in malignant brain tumors 1 protein

Protein Summary
Description
May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Bi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330163
  • ENSP00000327747
  • ENSG00000187908
  • ENST00000338354
  • ENSP00000342210
  • ENST00000344338
  • ENSP00000343175
  • ENST00000368909
  • ENSP00000357905
  • ENST00000368955
  • ENSP00000357951
  • ENST00000368956
  • ENSP00000357952
  • ENST00000619379
  • ENSP00000484603

Symbol
  • GP340
  • SAG
  • GP340
  • SALSA
  • muclin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
cell type or tissue
0.77
protein domain
0.73
cellular component
0.7
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.22   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 271.22   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0