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Tbio
DMBT1
Deleted in malignant brain tumors 1 protein

Protein Summary
Description
May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Bi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330163
  • ENSP00000327747
  • ENSG00000187908
  • ENST00000338354
  • ENSP00000342210
  • ENST00000344338
  • ENSP00000343175
  • ENST00000368909
  • ENSP00000357905
  • ENST00000368955
  • ENSP00000357951
  • ENST00000368956
  • ENSP00000357952
  • ENST00000619379
  • ENSP00000484603

Symbol
  • GP340
  • SAG
  • GP340
  • SALSA
  • muclin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
cell type or tissue
0.77
protein domain
0.73
cellular component
0.7
tissue sample
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.05   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 312.05   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999998353
p_ni:  0.000001647
Data Source:  BioPlex
PCK2
Tbio
Family:  Kinase
Novelty:  0.0035563
p_int:  0.999920634
p_ni:  0.000079366
Score:  0.17
Data Source:  BioPlex,STRINGDB
FRMD1
Tdark
Novelty:  0.96833141
p_int:  0.991714409
p_ni:  0.008285591
Data Source:  BioPlex
HBM
Tdark
Novelty:  0.02658671
p_int:  0.991589174
p_ni:  0.008410826
Score:  0.255
Data Source:  BioPlex,STRINGDB
ICE2
Tbio
Novelty:  0.03407933
p_int:  0.987474169
p_ni:  0.012525827
p_wrong:  3e-9
Score:  0.261
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.979662662
p_ni:  0.020337206
p_wrong:  1.32e-7
Score:  0.29
Data Source:  BioPlex,STRINGDB
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.976947182
p_ni:  0.023052705
p_wrong:  1.14e-7
Data Source:  BioPlex
HINT2
Tbio
Novelty:  0.09560851
p_int:  0.947947539
p_ni:  0.04412047
p_wrong:  0.007931991
Data Source:  BioPlex
COG2
Tbio
Novelty:  0.03109287
p_int:  0.909025001
p_ni:  0.069003736
p_wrong:  0.021971262
Data Source:  BioPlex
SFTPD
Tbio
Novelty:  0.00120012
Score:  0.988
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Surfactant metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Surfactant metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
0
1.9
98.1
disease progression measurement
1
1
0
2.1
83
3
3
3
70.9
1
1
0
2.1
67.9
systolic blood pressure
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
98.1
disease progression measurement
0
2.1
83
3
70.9
0
2.1
67.9
systolic blood pressure
1
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
deleted in malignant brain tumors 1
466221
Mouse
MGI:106210
12945
Dog
deleted in malignant brain tumors 1
VGNC:39996
486922
Zebrafish
ZDB-GENE-041210-146
558392
Species
Name
OMA
EggNOG
Inparanoid
Chimp
deleted in malignant brain tumors 1
Mouse
Dog
deleted in malignant brain tumors 1
Zebrafish
Publication Statistics
PubMed Score 312.05
PubMed score by year
PubTator Score 195.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title