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Tbio
DMAP1
DNA methyltransferase 1-associated protein 1

Protein Summary
Description
Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may al ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315913
  • ENSP00000312697
  • ENSG00000178028
  • ENST00000361745
  • ENSP00000354697
  • ENST00000372289
  • ENSP00000361363

Symbol
  • KIAA1425
  • EAF2
  • SWC4
  • MEAF2
  • DNMAP1
  • DNMTAP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
hub protein
0.96
histone modification site profile
0.91
biological process
0.87
transcription factor binding site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.26   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.26   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
VPS72
Tbio
Novelty:  0.00561093
p_int:  0.999998524
p_ni:  0.000001476
Score:  0.999
Data Source:  BioPlex,STRINGDB
AJUBA
Tbio
Novelty:  0.03561829
p_int:  0.999998277
p_ni:  0.000001706
p_wrong:  1.7e-8
Data Source:  BioPlex
MBTD1
Tbio
Family:  Epigenetic
Novelty:  0.11651052
p_int:  0.999998213
p_ni:  0.000001787
Score:  0.331
Data Source:  BioPlex,STRINGDB
EPC1
Tbio
Novelty:  0.03216371
p_int:  0.999997877
p_ni:  0.00000212
p_wrong:  3e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
DNMT1
Tclin
Family:  Enzyme
Novelty:  0.00042336
p_int:  0.9999959
p_ni:  0.0000041
Score:  0.882
Data Source:  BioPlex,STRINGDB
ZNHIT1
Tbio
Novelty:  0.00390514
p_int:  0.999990999
p_ni:  0.000008949
p_wrong:  5.3e-8
Score:  0.756
Data Source:  BioPlex,STRINGDB
SRCAP
Tbio
Family:  Enzyme
Novelty:  0.02446238
p_int:  0.999987222
p_ni:  0.000012778
Score:  0.983
Data Source:  BioPlex,STRINGDB
TUFT1
Tbio
Novelty:  0.01999031
p_int:  0.999984196
p_ni:  0.000014039
p_wrong:  0.000001765
Data Source:  BioPlex
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999979957
p_ni:  0.000020043
Score:  0.768
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999976318
p_ni:  0.000023682
Score:  0.595
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
67.1
self reported educational attainment
1
1
1
42.6
mathematical ability
1
1
1
2
brain measurement
1
1
0
5.5
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
67.1
self reported educational attainment
1
42.6
mathematical ability
1
2
brain measurement
0
5.5
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 1 associated protein 1
VGNC:6772
456517
Macaque
DNA methyltransferase 1 associated protein 1
702919
Mouse
MGI:1913483
66233
Rat
RGD:1311295
298447
Dog
DNA methyltransferase 1 associated protein 1
VGNC:39995
475385
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 1 associated protein 1
Macaque
DNA methyltransferase 1 associated protein 1
Mouse
Rat
Dog
DNA methyltransferase 1 associated protein 1
Publication Statistics
PubMed Score 36.26
PubMed score by year
PubTator Score 11.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text