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Tbio
DLX6
Homeobox protein DLX-6

Protein Summary
Description
This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000518156
  • ENSP00000428480
  • ENSG00000006377
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
cell type or tissue
0.78
protein domain
0.73
PubMedID
0.63
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.44   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.44   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
SEMG2
Tbio
Novelty:  0.06325799
p_int:  0.999999616
p_ni:  3.84e-7
Data Source:  BioPlex
SEMG1
Tbio
Novelty:  0.0161449
p_int:  0.999999371
p_ni:  6.29e-7
Data Source:  BioPlex
RNASEH2C
Tbio
Family:  Enzyme
Novelty:  0.06148299
p_int:  0.999978361
p_ni:  0.000021636
p_wrong:  3e-9
Data Source:  BioPlex
DCAF5
Tdark
Novelty:  0.39565074
p_int:  0.997011501
p_ni:  0.002988499
Data Source:  BioPlex
XRCC1
Tbio
Novelty:  0.00084203
p_int:  0.987482047
p_ni:  0.012516865
p_wrong:  0.000001088
Data Source:  BioPlex
PAXX
Tbio
Novelty:  0.03754932
p_int:  0.985310072
p_ni:  0.007668248
p_wrong:  0.007021679
Data Source:  BioPlex
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.982642191
p_ni:  0.017357809
Data Source:  BioPlex
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.978976452
p_ni:  0.021023089
p_wrong:  4.59e-7
Data Source:  BioPlex
KLHL42
Tdark
Novelty:  0.25822395
p_int:  0.974337069
p_ni:  0.025662281
p_wrong:  6.5e-7
Data Source:  BioPlex
CBX5
Tbio
Family:  Epigenetic
Novelty:  0.00653413
p_int:  0.972778996
p_ni:  0.027220585
p_wrong:  4.2e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of RUNX2 expression and activity
Reactome
Transcriptional regulation by RUNX2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of RUNX2 expression and activity
Transcriptional regulation by RUNX2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
10
94.9
smoking status measurement
2
1
2
64.9
smoking behavior
1
1
1
40.7
smoking behaviour measurement
1
1
1
35
bone density
1
2
2
28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
10
94.9
smoking status measurement
2
64.9
smoking behavior
1
40.7
smoking behaviour measurement
1
35
bone density
2
28
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 6
VGNC:4332
472452
Mouse
MGI:101927
13396
Dog
distal-less homeobox 6
VGNC:54763
482312
Cow
distal-less homeobox 6
VGNC:28102
786461
Opossum
distal-less homeobox 6 [Source:HGNC Symbol;Acc:HGNC:2919]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 6
Mouse
Dog
distal-less homeobox 6
Cow
distal-less homeobox 6
Opossum
distal-less homeobox 6 [Source:HGNC Symbol;Acc:HGNC:2919]
Publication Statistics
PubMed Score 58.44
PubMed score by year
PubTator Score 27.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title