Tbio DLX4 Homeobox protein DLX-4

Protein Summary

Description

May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis. Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q92988
• D3DTX2
• D3DTX3
• O60480
• Q13265
• Q6PJK0
• Q9HBE0

Gene Name

• DLX4

Ensembl ID

• ENST00000240306
• ENSP00000240306
• ENSG00000108813
• ENST00000411890
• ENSP00000410622
• ENST00000611342
• ENSP00000480366

Symbol

• BP1
• DLX7
• DLX8
• DLX9
• BP1
• DLX7
• DLX8
• DLX9
• OFC15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
transcription factor	0.77
protein domain	0.73
PubMedID	0.7
histone modification site profile	0.65

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Dlx-4

Protein / Nucleic Acid Binding / Dna Binding Protein / Homeobox Protein Dlx-4

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Dlx-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.19   (req: < 5)

Gene RIFs: 36   (req: <= 3)

Antibodies: 390   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.19   (req: >= 5)

Gene RIFs: 36   (req: > 3)

Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0