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Tbio
DLX4
Homeobox protein DLX-4

Protein Summary
Description
May play a role in determining the production of hemoglobin S. May act as a repressor. During embryonic development, plays a role in palatogenesis. Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240306
  • ENSP00000240306
  • ENSG00000108813
  • ENST00000411890
  • ENSP00000410622
  • ENST00000611342
  • ENSP00000480366

Symbol
  • BP1
  • DLX7
  • DLX8
  • DLX9
  • BP1
  • DLX7
  • DLX8
  • DLX9
  • OFC15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.79
transcription factor
0.77
protein domain
0.73
PubMedID
0.7
histone modification site profile
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.58   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 390   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.58   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 390   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
GPC6
Tbio
Novelty:  0.01951872
p_int:  0.879617943
p_ni:  0.120382057
Score:  0.372
Data Source:  BioPlex,STRINGDB
DIS3
Tbio
Family:  Enzyme
Novelty:  0.00961238
p_int:  0.872465961
p_ni:  0.127534039
Score:  0.195
Data Source:  BioPlex,STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
Score:  0.65
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.552
Data Source:  STRINGDB
ISL1
Tbio
Family:  TF
Novelty:  0.00169431
Score:  0.534
Data Source:  STRINGDB
TGIF2LX
Tbio
Family:  TF
Novelty:  0.10755032
Score:  0.53
Data Source:  STRINGDB
MEIS2
Tbio
Family:  TF
Novelty:  0.01393828
Score:  0.53
Data Source:  STRINGDB
ECSIT
Tbio
Novelty:  0.04690184
Score:  0.514
Data Source:  STRINGDB
IRX1
Tbio
Family:  TF
Novelty:  0.01754936
Score:  0.514
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.499
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2
0
1.1
77.6
balding measurement
1
1
1
11
blood urea nitrogen measurement
2
2
2
10.1
alkaline phosphatase measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
77.6
balding measurement
1
11
blood urea nitrogen measurement
2
10.1
alkaline phosphatase measurement
1
1.7
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 4
VGNC:9260
455109
Macaque
distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917]
Mouse
MGI:94904
13394
Rat
RGD:1308744
303469
Dog
distal-less homeobox 4
VGNC:53207
609214
Species
Name
OMA
EggNOG
Inparanoid
Chimp
distal-less homeobox 4
Macaque
distal-less homeobox 4 [Source:HGNC Symbol;Acc:HGNC:2917]
Mouse
Rat
Dog
distal-less homeobox 4
Publication Statistics
PubMed Score 64.58
PubMed score by year
PubTator Score 47.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title