Protein Summary
May have a role in neuroendocrine differentiation. This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
- ENST00000331224
- ENSP00000331081
- ENSG00000185559
- ENST00000341267
- ENSP00000340292
- ENST00000650464
- ENSP00000497700
- DLK
- DLK
- FA1
- ZOG
- pG2
- DLK-1
- PREF1
- Delta1
- Pref-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.99 | ||
gene perturbation | 0.98 | ||
disease perturbation | 0.79 | ||
biological term | 0.75 | ||
small molecule perturbation | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 550.04 (req: < 5)
Gene RIFs: 94 (req: <= 3)
Antibodies: 570 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 550.04 (req: >= 5)
Gene RIFs: 94 (req: > 3)
Antibodies: 570 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (10)
Protein-Protein Interactions (126)
ACVR2B
Family: Kinase
Novelty: 0.00555742
p_int: 0.999995284
p_ni: 0.000004709
p_wrong: 6e-9
Score: 0.197
Data Source: BioPlex,STRINGDB
ANKRD13C
Novelty: 1.5309683
p_int: 0.999991605
p_ni: 0.00000348
p_wrong: 0.000004915
Data Source: BioPlex
UBE3B
Family: Enzyme
Novelty: 0.06274049
p_int: 0.999981741
p_ni: 0.000018258
p_wrong: 1e-9
Score: 0.241
Data Source: BioPlex,STRINGDB
TMEM94
Novelty: 0.39746809
p_int: 0.999813527
p_ni: 0.000186471
p_wrong: 2e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
CABLES2
Novelty: 0.35458236
p_int: 0.999547757
p_ni: 0.000162765
p_wrong: 0.000289479
Score: 0.647
Data Source: BioPlex,STRINGDB
CABLES1
Novelty: 0.04822454
p_int: 0.998943186
p_ni: 0.000064717
p_wrong: 0.000992098
Score: 0.543
Data Source: BioPlex,STRINGDB
LAPTM4B
Novelty: 0.01162533
p_int: 0.99824615
p_ni: 0.001724771
p_wrong: 0.000029079
Data Source: BioPlex
SCAMP1
Novelty: 0.03293648
p_int: 0.997861285
p_ni: 0.002138557
p_wrong: 1.58e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (21)
Reactome (4)
PathwayCommons (4)
WikiPathways (13)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by NOTCH | ||||
Reactome | Signaling by NOTCH1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activated NOTCH1 Transmits Signal to the Nucleus | ||||
Signal Transduction | ||||
Signaling by NOTCH | ||||
Signaling by NOTCH1 | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (3)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (32)
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 5 | 5 | 5 | 2.1 | 94.5 | ||||
platelet crit | 2 | 3 | 4 | 94.3 | |||||
mosaic loss of chromosome Y measurement | 3 | 2 | 3 | 85.1 | |||||
body height | 2 | 2 | 2 | 74.5 | |||||
3 | 2 | 2 | 1.1 | 67.5 | |||||
Items per page:
1 – 5 of 32
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 5 | 2.1 | 94.5 | ||||
platelet crit | 4 | 94.3 | |||||
mosaic loss of chromosome Y measurement | 3 | 85.1 | |||||
body height | 2 | 74.5 | |||||
2 | 1.1 | 67.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | delta like non-canonical Notch ligand 1 | 707595 | ||||||
Mouse | MGI:94900 | 13386 | ||||||
Rat | RGD:619931 | 114587 | ||||||
Dog | delta like non-canonical Notch ligand 1 | VGNC:39984 | 490860 | |||||
Horse | delta like non-canonical Notch ligand 1 | VGNC:17216 | 100054933 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | delta like non-canonical Notch ligand 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | delta like non-canonical Notch ligand 1 | |||||
Horse | delta like non-canonical Notch ligand 1 | |||||
Publication Statistics
PubMed Score 550.04
PubMed score by year
PubTator Score 457.69
PubTator score by year
Related Publications
Text Mined References (140)
GeneRif Annotations (94)
Items per page:
0 of 0
PMID | Year | Title |
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