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Tchem
DLK1
Protein delta homolog 1

Protein Summary
Description
May have a role in neuroendocrine differentiation. This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331224
  • ENSP00000331081
  • ENSG00000185559
  • ENST00000341267
  • ENSP00000340292
  • ENST00000650464
  • ENSP00000497700

Symbol
  • DLK
  • DLK
  • FA1
  • ZOG
  • pG2
  • DLK-1
  • PREF1
  • Delta1
  • Pref-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.99
gene perturbation
0.98
disease perturbation
0.79
biological term
0.75
small molecule perturbation
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 633.75   (req: < 5)
Gene RIFs: 94   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 633.75   (req: >= 5)
Gene RIFs: 94   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1