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Tbio
DLGAP5
Disks large-associated protein 5

Protein Summary
Description
Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247191
  • ENSP00000247191
  • ENSG00000126787
  • ENST00000395425
  • ENSP00000378815

Symbol
  • DLG7
  • KIAA0008
  • DLG7
  • HURP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.93
histone modification site profile
0.83
co-expressed gene
0.72
small molecule perturbation
0.72
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.67   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 87.67   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0