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Tbio
DLGAP4
Disks large-associated protein 4

Protein Summary
Description
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. The product of this gene is a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. It is a signaling molecule that can interact with potassium channels and receptors, as well as other signaling molecules. The protein encoded by this gene can interact with PSD-95 through its guanylate kinase domain and may be involved in clustering PSD-95 in the postsynaptic density region. The encoded protein is one of at least four similar proteins that have been found. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339266
  • ENSP00000341633
  • ENSG00000080845
  • ENST00000340491
  • ENSP00000345700
  • ENST00000373907
  • ENSP00000363014
  • ENST00000373913
  • ENSP00000363023
  • ENST00000401952
  • ENSP00000384954

Symbol
  • DAP4
  • KIAA0964
  • SAPAP4
  • DAP4
  • DLP4
  • DAP-4
  • SAPAP4
  • SAPAP-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
hub protein
0.88
transcription factor perturbation
0.88
transcription factor
0.84
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
DLG4
Tchem
Novelty:  0.00057285
Score:  0.993
Data Source:  Reactome,STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.988
Data Source:  Reactome,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.982
Data Source:  Reactome,STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.981
Data Source:  Reactome,STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.981
Data Source:  Reactome,STRINGDB
DLGAP3
Tbio
Novelty:  0.02019435
Score:  0.98
Data Source:  STRINGDB
DLGAP2
Tbio
Novelty:  0.02137009
Score:  0.978
Data Source:  STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
Score:  0.94
Data Source:  Reactome,STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.928
Data Source:  Reactome,STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
1
2
2
94.9
appendicular lean mass
1
3
3
68.5
1
1
0
1.3
60.5
BMI-adjusted hip circumference
1
2
2
52.7
mean corpuscular hemoglobin concentration
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
suntan
2
94.9
appendicular lean mass
3
68.5
0
1.3
60.5
BMI-adjusted hip circumference
2
52.7
mean corpuscular hemoglobin concentration
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DLG associated protein 4
702928
Mouse
MGI:2138865
228836
Rat
RGD:708350
286930
Dog
DLG associated protein 4
VGNC:39982
477219
Horse
DLG associated protein 4
VGNC:17215
100055151
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DLG associated protein 4
Mouse
Rat
Dog
DLG associated protein 4
Horse
DLG associated protein 4
Publication Statistics
PubMed Score 21.65
PubMed score by year
PubTator Score 11.63
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title