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Tbio
DLGAP3
Disks large-associated protein 3

Protein Summary
Description
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000235180
  • ENSP00000235180
  • ENSG00000116544
  • ENST00000373347
  • ENSP00000362444

Symbol
  • DAP3
  • DAP3
  • SAPAP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.68
hub protein
0.67
PubMedID
0.61
cell line
0.49
tissue sample
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.56   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.56   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
DLGAP2
Tbio
Novelty:  0.02137009
Score:  0.996
Data Source:  STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.992
Data Source:  Reactome,STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.991
Data Source:  Reactome,STRINGDB
DLGAP1
Tbio
Novelty:  0.01576595
Score:  0.989
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.987
Data Source:  Reactome,STRINGDB
DLGAP4
Tbio
Novelty:  0.06240351
Score:  0.98
Data Source:  STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.971
Data Source:  Reactome,STRINGDB
DLG3
Tbio
Novelty:  0.01196565
Score:  0.966
Data Source:  Reactome,STRINGDB
GRM5
Tchem
Family:  GPCR
Novelty:  0.00062552
Score:  0.955
Data Source:  Reactome,STRINGDB
NLGN3
Tbio
Family:  Enzyme
Novelty:  0.00819625
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
48.5
myeloid white cell count
1
1
1
48.5
intraocular pressure measurement
1
1
0
6.2
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
48.5
myeloid white cell count
1
48.5
intraocular pressure measurement
0
6.2
37.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 3
VGNC:6769
100612766
Macaque
DLG associated protein 3
711238
Mouse
MGI:3039563
242667
Rat
RGD:708349
286923
Dog
DLG associated protein 3
VGNC:39981
475342
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 3
Macaque
DLG associated protein 3
Mouse
Rat
Dog
DLG associated protein 3
Publication Statistics
PubMed Score 59.56
PubMed score by year
PubTator Score 14.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title