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Tbio
DLGAP2
Disks large-associated protein 2

Protein Summary
Description
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane. The product of this gene is a membrane-associated protein that may play a role in synapse organization and signalling in neuronal cells. This gene is biallelically expressed in the brain, however, only the paternal allele is expressed in the testis (PMID:18055845). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000421627
  • ENSP00000400258
  • ENSG00000198010

Symbol
  • C8orf68
  • DAP2
  • ERICH1-AS1
  • DAP2
  • SAPAP2
  • C8orf68
  • ERICH1-AS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.96
hub protein
0.94
microRNA
0.89
cell line
0.65
gene perturbation
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.16   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.16   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
DLGAP3
Tbio
Novelty:  0.02019435
Score:  0.996
Data Source:  STRINGDB
SHANK2
Tbio
Novelty:  0.00710548
Score:  0.995
Data Source:  Reactome,STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.99
Data Source:  Reactome,STRINGDB
DLGAP1
Tbio
Novelty:  0.01576595
Score:  0.989
Data Source:  STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.979
Data Source:  Reactome,STRINGDB
DLGAP4
Tbio
Novelty:  0.06240351
Score:  0.978
Data Source:  STRINGDB
DLG2
Tbio
Novelty:  0.00999909
Score:  0.969
Data Source:  Reactome,STRINGDB
NLGN4X
Tbio
Family:  Enzyme
Novelty:  0.01004489
Score:  0.968
Data Source:  STRINGDB
P58400
Tbio
Novelty:  0.00454659
Score:  0.963
Data Source:  STRINGDB
Q9ULB1
Tbio
Novelty:  0.00454659
Score:  0.963
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
57.8
neuroticism measurement
1
3
0
5.6
46.5
self reported educational attainment
1
2
2
37.3
triglyceride measurement
1
1
0
1.3
27.3
feeling miserable measurement
1
1
0
5.6
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
57.8
neuroticism measurement
0
5.6
46.5
self reported educational attainment
2
37.3
triglyceride measurement
0
1.3
27.3
feeling miserable measurement
0
5.6
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 2
VGNC:50426
463960
Mouse
MGI:2443181
244310
Rat
RGD:620224
116681
Dog
DLG associated protein 2
VGNC:39980
488556
Horse
DLG associated protein 2
VGNC:17213
100065394
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DLG associated protein 2
Mouse
Rat
Dog
DLG associated protein 2
Horse
DLG associated protein 2
Publication Statistics
PubMed Score 47.16
PubMed score by year
PubTator Score 23.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title