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Tbio
DLG2
Disks large homolog 2

Protein Summary
Description
Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280241
  • ENSP00000280241
  • ENSG00000150672
  • ENST00000376104
  • ENSP00000365272
  • ENST00000398309
  • ENSP00000381355
  • ENST00000418306
  • ENSP00000402275
  • ENST00000426717
  • ENSP00000393049

Symbol
  • PSD93
  • PSD-93
  • PPP1R58
  • chapsyn-110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
transcription factor
0.93
phenotype
0.78
transcription factor binding site profile
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.64   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.64   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
DLG3
Tbio
Novelty:  0.01196565
p_int:  0.99999847
p_ni:  4.6e-8
p_wrong:  0.000001484
Score:  0.929
Data Source:  BioPlex,STRINGDB
DLGAP1
Tbio
Novelty:  0.01576595
Score:  0.993
Data Source:  Reactome,STRINGDB
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
Score:  0.985
Data Source:  Reactome,STRINGDB
GRIN2B
Tclin
Family:  IC
Novelty:  0.00035058
Score:  0.985
Data Source:  Reactome,STRINGDB
DLGAP4
Tbio
Novelty:  0.06240351
Score:  0.981
Data Source:  Reactome,STRINGDB
BEGAIN
Tbio
Family:  Enzyme
Novelty:  0.18303898
Score:  0.977
Data Source:  Reactome,STRINGDB
GRIN1
Tclin
Family:  IC
Novelty:  0.0011807
Score:  0.975
Data Source:  Reactome,STRINGDB
DLGAP3
Tbio
Novelty:  0.02019435
Score:  0.971
Data Source:  Reactome,STRINGDB
SHANK1
Tbio
Novelty:  0.01475447
Score:  0.97
Data Source:  Reactome,STRINGDB
DLGAP2
Tbio
Novelty:  0.02137009
Score:  0.969
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
2
2
0
21
89.7
refractive error
2
2
2
7.8
88
Myopia
2
1
0
4.4
84.6
1
1
0
1.3
84.5
influenza A (H1N1)
2
1
0
11.9
80.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
putamen volume
0
21
89.7
refractive error
2
7.8
88
Myopia
0
4.4
84.6
0
1.3
84.5
influenza A (H1N1)
0
11.9
80.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
discs large MAGUK scaffold protein 2
VGNC:11340
466728
Macaque
discs large MAGUK scaffold protein 2
704826
Mouse
MGI:1344351
23859
Rat
RGD:619895
64053
Dog
discs large MAGUK scaffold protein 2
VGNC:39978
485158
Species
Name
OMA
EggNOG
Inparanoid
Chimp
discs large MAGUK scaffold protein 2
Macaque
discs large MAGUK scaffold protein 2
Mouse
Rat
Dog
discs large MAGUK scaffold protein 2
Publication Statistics
PubMed Score 105.64
PubMed score by year
PubTator Score 35.30
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title