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Tbio
DLG1
Disks large homolog 1

Protein Summary
Description
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. This gene encodes a multi-domain scaffolding protein that is required for normal development. This protein may have a role in septate junction formation, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. A multitude of transcript variants deriving from alternative splicing and the use of multiple alternate promoter have been observed, including some splice variants that may be specific to brain and other tissues. An upstream uORF may regulate translation at some splice variants of this gen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346964
  • ENSP00000345731
  • ENSG00000075711
  • ENST00000392382
  • ENSP00000376187
  • ENST00000419354
  • ENSP00000407531
  • ENST00000422288
  • ENSP00000413238
  • ENST00000443183
  • ENSP00000396658
  • ENST00000448528
  • ENSP00000391732
  • ENST00000450955
  • ENSP00000411278
  • ENST00000452595
  • ENSP00000398939

Symbol
  • hdlg
  • DLGH1
  • SAP97
  • SAP-97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
protein domain
1
viral protein
1
virus
1
molecular function
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.47   (req: < 5)
Gene RIFs: 91   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.47   (req: >= 5)
Gene RIFs: 91   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 66
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0