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Tbio
DLAT
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Protein Summary
Description
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280346
  • ENSP00000280346
  • ENSG00000150768

Symbol
  • DLTA
  • E2
  • DLTA
  • PDCE2
  • PDC-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
kinase perturbation
0.97
transcription factor perturbation
0.94
protein domain
0.92
virus perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.53   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.53   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
PDK3
Tchem
Family:  Kinase
Novelty:  0.05009442
p_int:  0.997679711
p_ni:  0.002320289
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PDHB
Tbio
Family:  Enzyme
Novelty:  0.01018086
p_int:  0.996133986
p_ni:  0.003866014
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
p_int:  0.9547131
p_ni:  0.0452869
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
FOXD4
Tbio
Family:  TF
Novelty:  0.11166611
p_int:  0.898755786
p_ni:  0.101244214
Score:  0.683
Data Source:  BioPlex,STRINGDB
MIF
Tchem
Novelty:  0.00056843
p_int:  0.783185858
p_ni:  0.216814142
Data Source:  BioPlex
PDHA1
Tbio
Family:  Enzyme
Novelty:  0.00392231
Score:  0.999
Data Source:  Reactome,STRINGDB
OGDH
Tbio
Family:  Enzyme
Novelty:  0.00674601
Score:  0.998
Data Source:  STRINGDB
CS
Tbio
Family:  Enzyme
Novelty:  0.00154214
Score:  0.997
Data Source:  STRINGDB
PDHA2
Tbio
Family:  Enzyme
Novelty:  0.06188763
Score:  0.997
Data Source:  Reactome,STRINGDB
DLST
Tbio
Family:  Enzyme
Novelty:  0.01516932
Score:  0.993
Data Source:  STRINGDB
Pathways (47)
Cell redox homeostasis (R-HSA-1222541)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell redox homeostasis
Reactome
Disease
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Infectious disease
Reactome
Latent infection - Other responses of Mtb to phagocytosis
Name
Explore in Pharos
Explore in Source
Cell redox homeostasis
Disease
Glyoxylate metabolism and glycine degradation
Infectious disease
Latent infection - Other responses of Mtb to phagocytosis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
3
3
90.6
interleukin 18 measurement
1
1
1
87.5
smoking status measurement
2
2
2
68.1
smoking initiation
1
1
1
39.6
BMI-adjusted waist-hip ratio
2
2
2
39.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
90.6
interleukin 18 measurement
1
87.5
smoking status measurement
2
68.1
smoking initiation
1
39.6
BMI-adjusted waist-hip ratio
2
39.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
dihydrolipoamide S-acetyltransferase
106992261
Mouse
MGI:2385311
235339
Dog
dihydrolipoamide S-acetyltransferase
VGNC:39974
489406
Horse
dihydrolipoamide S-acetyltransferase
VGNC:17206
100062027
Pig
dihydrolipoamide S-acetyltransferase
397054
Species
Name
OMA
EggNOG
Inparanoid
Macaque
dihydrolipoamide S-acetyltransferase
Mouse
Dog
dihydrolipoamide S-acetyltransferase
Horse
dihydrolipoamide S-acetyltransferase
Pig
dihydrolipoamide S-acetyltransferase
Publication Statistics
PubMed Score 341.53
PubMed score by year
PubTator Score 203.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title