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Tbio
DKKL1
Dickkopf-like protein 1

Protein Summary
Description
Involved in fertilization by facilitating sperm penetration of the zona pellucida. May promotes spermatocyte apoptosis, thereby limiting sperm production. In adults, may reduces testosterone synthesis in Leydig cells. Is not essential either for development or fertility. The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221498
  • ENSP00000221498
  • ENSG00000104901

Symbol
  • SGY1
  • SGY
  • CT34
  • SGY1
  • SGY-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
gene perturbation
0.65
cell type or tissue
0.57
PubMedID
0.56
phenotype
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.59   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 270.59   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
PCDHGA11
Tdark
Novelty:  0.44130091
p_int:  0.999989959
p_ni:  0.000010041
Data Source:  BioPlex
PEX6
Tbio
Family:  Enzyme
Novelty:  0.00874708
p_int:  0.999958817
p_ni:  0.000041183
Data Source:  BioPlex
NUCB1
Tchem
Novelty:  0.0040312
p_int:  0.999952017
p_ni:  0.000047983
Data Source:  BioPlex
PCSK1N
Tbio
Novelty:  0.02656799
p_int:  0.99985662
p_ni:  0.000026439
p_wrong:  0.00011694
Data Source:  BioPlex
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.999707583
p_ni:  0.000292356
p_wrong:  6.1e-8
Data Source:  BioPlex
MGAT4B
Tbio
Family:  Enzyme
Novelty:  0.11244606
p_int:  0.999517583
p_ni:  0.00047113
p_wrong:  0.000011287
Data Source:  BioPlex
FAT4
Tbio
Novelty:  0.01739918
p_int:  0.999492176
p_ni:  0.000507824
Data Source:  BioPlex
RAD51B
Tbio
Novelty:  0.00302521
p_int:  0.999410786
p_ni:  0.000589213
p_wrong:  1e-9
Data Source:  BioPlex
XRCC2
Tbio
Novelty:  0.00862049
p_int:  0.998991236
p_ni:  0.000135882
p_wrong:  0.000872882
Score:  0.527
Data Source:  BioPlex,STRINGDB
CELSR2
Tbio
Family:  GPCR
Novelty:  0.02657319
p_int:  0.998989188
p_ni:  0.001010812
Score:  0.489
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
3
3
0
1.1
93.9
blood protein measurement
14
8
14
93.4
serum albumin measurement
1
2
2
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
multiple sclerosis
0
1.1
93.9
blood protein measurement
14
93.4
serum albumin measurement
2
59.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dickkopf like acrosomal protein 1
VGNC:7690
456202
Macaque
dickkopf like acrosomal protein 1
718731
Mouse
MGI:1354963
50722
Rat
RGD:1563523
499150
Dog
dickkopf like acrosomal protein 1
VGNC:39973
610302
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dickkopf like acrosomal protein 1
Macaque
dickkopf like acrosomal protein 1
Mouse
Rat
Dog
dickkopf like acrosomal protein 1
Publication Statistics
PubMed Score 270.59
PubMed score by year
PubTator Score 32.55
PubTator score by year
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Related Publications
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PMID
Year
Title