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Tbio
DIXDC1
Dixin

Protein Summary
Description
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000440460
  • ENSP00000394352
  • ENSG00000150764
  • ENST00000529225
  • ENSP00000434130
  • ENST00000615255
  • ENSP00000480808

Symbol
  • CCD1
  • KIAA1735
  • CCD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
transcription factor perturbation
0.84
transcription factor
0.79
biological process
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.38   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.38   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
NDEL1
Tbio
Novelty:  0.01241819
p_int:  1
Score:  0.636
Data Source:  BioPlex,STRINGDB
FAM124A
Tdark
Novelty:  1.51577847
p_int:  0.999999884
p_ni:  1.15e-7
p_wrong:  1e-9
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999998047
p_ni:  0.000001945
p_wrong:  8e-9
Data Source:  BioPlex
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.999993625
p_ni:  0.000006275
p_wrong:  1e-7
Data Source:  BioPlex
L3HYPDH
Tdark
Family:  Enzyme
Novelty:  0.35456591
p_int:  0.999971131
p_ni:  0.000028869
Score:  0.282
Data Source:  BioPlex,STRINGDB
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
Score:  0.763
Data Source:  STRINGDB
DISC1
Tbio
Novelty:  0.00183442
Score:  0.754
Data Source:  STRINGDB
AXIN1
Tbio
Novelty:  0.00175842
Score:  0.73
Data Source:  STRINGDB
CDK5
Tchem
Family:  Kinase
Novelty:  0.00071394
Score:  0.713
Data Source:  STRINGDB
DLAT
Tbio
Family:  Enzyme
Novelty:  0.00311191
Score:  0.712
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
71.6
BMI-adjusted waist circumference
2
3
3
58.9
BMI-adjusted waist-hip ratio
4
3
6
58.5
mean platelet volume
1
1
1
38.8
serum gamma-glutamyl transferase measurement
1
1
1
37
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
71.6
BMI-adjusted waist circumference
3
58.9
BMI-adjusted waist-hip ratio
6
58.5
mean platelet volume
1
38.8
serum gamma-glutamyl transferase measurement
1
37
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DIX domain containing 1
710847
Mouse
MGI:2679721
330938
Rat
RGD:1309902
363062
Dog
DIX domain containing 1
VGNC:39969
608957
Horse
DIX domain containing 1
VGNC:17200
100061990
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DIX domain containing 1
Mouse
Rat
Dog
DIX domain containing 1
Horse
DIX domain containing 1
Publication Statistics
PubMed Score 27.38
PubMed score by year
PubTator Score 28.45
PubTator score by year
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Related Publications
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PMID
Year
Title