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Tbio
DISP1
Protein dispatched homolog 1

Protein Summary
Description
Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal (By similarity). Synergizes with SCUBE2 to cause a increase in SHH secretion (PubMed:22902404). The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protei ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284476
  • ENSP00000284476
  • ENSG00000154309

Symbol
  • DISPA
  • DISPA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
cell type or tissue
0.64
cell line
0.58
tissue sample
0.53
phenotype
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.71   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.71   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
CST2
Tbio
Novelty:  0.02114441
p_int:  0.999028825
p_ni:  0.000862705
p_wrong:  0.00010847
Data Source:  BioPlex
C15orf32
Tdark
Novelty:  8.4527027
p_int:  0.998640109
p_ni:  1.51e-7
p_wrong:  0.001359739
Data Source:  BioPlex
IL17RC
Tclin
Novelty:  0.01844832
p_int:  0.85005732
p_ni:  0.000012484
p_wrong:  0.149930197
Score:  0.269
Data Source:  BioPlex,STRINGDB
ANXA1
Tbio
Novelty:  0.00103537
p_int:  0.824600485
p_ni:  0.175399515
Data Source:  BioPlex
CST4
Tbio
Novelty:  0.00773554
p_int:  0.788662898
p_ni:  0.208196049
p_wrong:  0.003141054
Data Source:  BioPlex
CRNN
Tbio
Novelty:  0.01648731
p_int:  0.754467315
p_ni:  0.243716237
p_wrong:  0.001816448
Data Source:  BioPlex
SHH
Tchem
Novelty:  0.00028347
Score:  0.984
Data Source:  STRINGDB
ZIC2
Tbio
Family:  TF
Novelty:  0.00900257
Score:  0.758
Data Source:  STRINGDB
SIX3
Tbio
Family:  TF
Novelty:  0.00599946
Score:  0.756
Data Source:  STRINGDB
NPHS1
Tbio
Novelty:  0.00104742
Score:  0.753
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
14
monocyte count
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
14
monocyte count
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dispatched RND transporter family member 1
VGNC:11311
457761
Macaque
dispatched RND transporter family member 1
703960
Mouse
MGI:1916147
68897
Rat
RGD:1307675
289338
Dog
dispatched RND transporter family member 1
VGNC:39966
488604
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dispatched RND transporter family member 1
Macaque
dispatched RND transporter family member 1
Mouse
Rat
Dog
dispatched RND transporter family member 1
Publication Statistics
PubMed Score 21.71
PubMed score by year
PubTator Score 10.70
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title