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Tbio
DISC1
Disrupted in schizophrenia 1 protein

Protein Summary
Description
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317586
  • ENSP00000320784
  • ENSG00000162946
  • ENST00000366633
  • ENSP00000355593
  • ENST00000366636
  • ENSP00000355596
  • ENST00000366637
  • ENSP00000355597
  • ENST00000439617
  • ENSP00000403888
  • ENST00000535983
  • ENSP00000443996
  • ENST00000539444
  • ENSP00000440953
  • ENST00000602281
  • ENSP00000473425
  • ENST00000602700
  • ENSP00000473417
  • ENST00000602713
  • ENSP00000473261
  • ENST00000602822
  • ENSP00000473586
  • ENST00000602873
  • ENSP00000473386
  • ENST00000628350
  • ENSP00000487190
  • ENST00000639374
  • ENSP00000491762

Symbol
  • KIAA0457
  • SCZD9
  • C1orf136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
cellular component
0.86
biological process
0.84
histone modification site profile
0.77
phenotype
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.84   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 586   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 665.84   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (185)
GRIPAP1
Tbio
Novelty:  0.09814766
p_int:  0.999999961
p_ni:  4e-8
Score:  0.177
Data Source:  BioPlex,STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
p_int:  0.999999956
p_ni:  4.3e-8
p_wrong:  1e-9
Data Source:  BioPlex
AP4B1
Tbio
Novelty:  0.08255831
p_int:  0.999999786
p_ni:  2.14e-7
Data Source:  BioPlex
AP4M1
Tbio
Novelty:  0.00142961
p_int:  0.999999441
p_ni:  5.59e-7
Data Source:  BioPlex
NDEL1
Tbio
Novelty:  0.01241819
p_int:  0.999999283
p_ni:  7.17e-7
Score:  0.934
Data Source:  BioPlex,STRINGDB
OFD1
Tbio
Novelty:  0.01032841
p_int:  0.999998006
p_ni:  0.000001994
Data Source:  BioPlex
MCM10
Tbio
Novelty:  0.0136058
p_int:  0.999981355
p_ni:  0.000018645
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999965062
p_ni:  0.000034938
Data Source:  BioPlex
RNF20
Tbio
Family:  Enzyme
Novelty:  0.01238827
p_int:  0.999955814
p_ni:  0.000044185
p_wrong:  1e-9
Data Source:  BioPlex
NDE1
Tbio
Novelty:  0.00567438
p_int:  0.999955134
p_ni:  0.000044866
Score:  0.733
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SYSCILIA_CCNET
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
55.2
periodontal measurement
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
55.2
periodontal measurement
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DISC1 scaffold protein
VGNC:53520
742093
Macaque
disrupted in schizophrenia 1
719086
Mouse
MGI:2447658
244667
Rat
RGD:631359
307940
Dog
DISC1 scaffold protein
VGNC:39965
488970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DISC1 scaffold protein
Macaque
disrupted in schizophrenia 1
Mouse
Rat
Dog
DISC1 scaffold protein
Publication Statistics
PubMed Score 665.84
PubMed score by year
PubTator Score 386.99
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title