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Tbio
DISC1
Disrupted in schizophrenia 1 protein

Protein Summary
Description
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation. This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317586
  • ENSP00000320784
  • ENSG00000162946
  • ENST00000366633
  • ENSP00000355593
  • ENST00000366636
  • ENSP00000355596
  • ENST00000366637
  • ENSP00000355597
  • ENST00000439617
  • ENSP00000403888
  • ENST00000535983
  • ENSP00000443996
  • ENST00000539444
  • ENSP00000440953
  • ENST00000602281
  • ENSP00000473425
  • ENST00000602700
  • ENSP00000473417
  • ENST00000602713
  • ENSP00000473261
  • ENST00000602822
  • ENSP00000473586
  • ENST00000602873
  • ENSP00000473386
  • ENST00000628350
  • ENSP00000487190
  • ENST00000639374
  • ENSP00000491762

Symbol
  • KIAA0457
  • SCZD9
  • C1orf136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
cellular component
0.86
biological process
0.84
histone modification site profile
0.77
phenotype
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.77   (req: < 5)
Gene RIFs: 217   (req: <= 3)
Antibodies: 586   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 745.77   (req: >= 5)
Gene RIFs: 217   (req: > 3)
Antibodies: 586   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0