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Tbio
DIS3L
DIS3-like exonuclease 1

Protein Summary
Description
Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319194
  • ENSP00000321583
  • ENSG00000166938
  • ENST00000319212
  • ENSP00000321711

Symbol
  • DIS3L1
  • KIAA1955
  • DIS3L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor
0.71
molecular function
0.67
tissue sample
0.64
cell line
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
EXOSC1
Tbio
Novelty:  0.01386842
p_int:  0.999999907
p_ni:  9.2e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC7
Tbio
Family:  Enzyme
Novelty:  0.07422851
p_int:  0.999999905
p_ni:  9.5e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC3
Tbio
Novelty:  0.03072164
p_int:  0.999999795
p_ni:  2.05e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOSC8
Tbio
Family:  Enzyme
Novelty:  0.02013403
p_int:  0.999999362
p_ni:  6.38e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
LIN9
Tbio
Novelty:  0.01112853
p_int:  0.999583474
p_ni:  0.000416523
p_wrong:  3e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
PIP
Tbio
Novelty:  0.00208509
p_int:  0.997124667
p_ni:  0.002875333
Data Source:  BioPlex
LCN15
Tdark
Novelty:  0.54935158
p_int:  0.99662373
p_ni:  0.003371539
p_wrong:  0.000004731
Score:  0.23
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.995796354
p_ni:  0.004203645
p_wrong:  1e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.988716446
p_ni:  0.011261197
p_wrong:  0.000022357
Data Source:  BioPlex
EXOSC4
Tbio
Family:  Enzyme
Novelty:  0.00798796
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
68.1
mathematical ability
2
2
2
68.1
mean corpuscular volume
1
1
1
54.4
1
1
0
1.2
44.2
self reported educational attainment
1
1
1
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
68.1
mathematical ability
2
68.1
mean corpuscular volume
1
54.4
0
1.2
44.2
self reported educational attainment
1
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DIS3 like exosome 3'-5' exoribonuclease
VGNC:10252
467710
Macaque
DIS3 like exosome 3'-5' exoribonuclease
710238
Mouse
MGI:2143272
213550
Rat
RGD:1308959
363077
Dog
DIS3 like exosome 3'-5' exoribonuclease
VGNC:39963
478346
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DIS3 like exosome 3'-5' exoribonuclease
Macaque
DIS3 like exosome 3'-5' exoribonuclease
Mouse
Rat
Dog
DIS3 like exosome 3'-5' exoribonuclease
Publication Statistics
PubMed Score 5.13
PubMed score by year
PubTator Score 3.12
PubTator score by year
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Related Publications
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PMID
Year
Title