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Tbio
DIS3
Exosome complex exonuclease RRP44

Protein Summary
Description
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377767
  • ENSP00000366997
  • ENSG00000083520
  • ENST00000377780
  • ENSP00000367011

Symbol
  • KIAA1008
  • RRP44
  • RRP44
  • dis3p
  • EXOSC11
  • KIAA1008
  • 2810028N01Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
interacting protein
0.89
histone modification site profile
0.83
transcription factor perturbation
0.74
molecular function
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.81   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.81   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0