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Tbio
DIS3
Exosome complex exonuclease RRP44

Protein Summary
Description
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377767
  • ENSP00000366997
  • ENSG00000083520
  • ENST00000377780
  • ENSP00000367011

Symbol
  • KIAA1008
  • RRP44
  • RRP44
  • dis3p
  • EXOSC11
  • KIAA1008
  • 2810028N01Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
interacting protein
0.89
histone modification site profile
0.83
transcription factor perturbation
0.74
molecular function
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.13   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.13   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (241)
DCX
Tbio
Novelty:  0.00077614
p_int:  0.999268835
p_ni:  0.000731165
Score:  0.211
Data Source:  BioPlex,STRINGDB
CD14
Tbio
Novelty:  0.00872424
p_int:  0.996901173
p_ni:  0.003098827
Data Source:  BioPlex
SSBP3
Tbio
Novelty:  0.01955714
p_int:  0.99615591
p_ni:  0.00384409
Score:  0.157
Data Source:  BioPlex,STRINGDB
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.995112405
p_ni:  0.004887595
Data Source:  BioPlex
RBM23
Tbio
Novelty:  0.03769792
p_int:  0.99479238
p_ni:  0.00520762
Score:  0.157
Data Source:  BioPlex,STRINGDB
GAS2L1
Tbio
Novelty:  0.17484834
p_int:  0.990230641
p_ni:  0.009769359
Score:  0.248
Data Source:  BioPlex,STRINGDB
C1D
Tbio
Novelty:  0.00997109
p_int:  0.988694391
p_ni:  0.011305609
Score:  0.994
Data Source:  BioPlex,STRINGDB
MUS81
Tbio
Family:  Enzyme
Novelty:  0.00532122
p_int:  0.978876506
p_ni:  0.021123494
Score:  0.205
Data Source:  BioPlex,STRINGDB
MPHOSPH6
Tbio
Family:  Enzyme
Novelty:  0.24387167
p_int:  0.974271243
p_ni:  0.025728757
Score:  0.984
Data Source:  BioPlex,STRINGDB
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.973113266
p_ni:  0.026886734
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Reactome
Deadenylation-dependent mRNA decay
Reactome
KSRP (KHSRP) binds and destabilizes mRNA
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Deadenylation-dependent mRNA decay
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
72.6
mean reticulocyte volume
1
1
1
71.2
red blood cell density measurement
1
1
1
56.2
red blood cell distribution width
1
1
1
33.1
mean corpuscular hemoglobin concentration
1
1
1
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
72.6
mean reticulocyte volume
1
71.2
red blood cell density measurement
1
56.2
red blood cell distribution width
1
33.1
mean corpuscular hemoglobin concentration
1
32.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
VGNC:9790
452595
Macaque
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
694048
Mouse
MGI:1919912
72662
Rat
RGD:1304646
306103
Dog
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
VGNC:39962
485491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Macaque
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Mouse
Rat
Dog
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
Publication Statistics
PubMed Score 117.13
PubMed score by year
PubTator Score 38.91
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title