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Tbio
DIRAS1
GTP-binding protein Di-Ras1

Protein Summary
Description
Displays low GTPase activity and exists predominantly in the GTP-bound form. DIRAS1 belongs to a distinct branch of the functionally diverse Ras (see HRAS; MIM 190020) superfamily of monomeric GTPases.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323469
  • ENSP00000325836
  • ENSG00000176490
  • ENST00000585334
  • ENSP00000468417

Symbol
  • GBTS1
  • RIG
  • RIG
  • GBTS1
  • Di-Ras1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
protein domain
0.58
histone modification site profile
0.52
tissue sample
0.48
biological process
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.16   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
RAP1GDS1
Tbio
Family:  Enzyme
Novelty:  0.06140479
p_int:  0.999999921
p_ni:  7.6e-8
p_wrong:  3e-9
Score:  0.683
Data Source:  BioPlex,STRINGDB
SLC9A5
Tchem
Family:  Transporter
Novelty:  0.05361766
p_int:  0.999895905
p_ni:  0.000087091
p_wrong:  0.000017004
Data Source:  BioPlex
LINC01587
Tdark
Novelty:  0.48128342
p_int:  0.999799773
p_ni:  0.000198785
p_wrong:  0.000001443
Score:  0.169
Data Source:  BioPlex,STRINGDB
SNX20
Tdark
Novelty:  0.28934317
p_int:  0.999620331
p_ni:  0.000329729
p_wrong:  0.00004994
Score:  0.211
Data Source:  BioPlex,STRINGDB
ARL4C
Tbio
Family:  Enzyme
Novelty:  0.04764628
p_int:  0.999601756
p_ni:  0.000398238
p_wrong:  6e-9
Score:  0.673
Data Source:  BioPlex,STRINGDB
AKR1D1
Tbio
Family:  Enzyme
Novelty:  0.01264297
p_int:  0.999544143
p_ni:  0.000455855
p_wrong:  2e-9
Score:  0.507
Data Source:  BioPlex,STRINGDB
GBA3
Tbio
Family:  Enzyme
p_int:  0.998498858
p_ni:  0.001477095
p_wrong:  0.000024047
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.998185826
p_ni:  0.001148206
p_wrong:  0.000665968
Data Source:  BioPlex
IL20RA
Tbio
Novelty:  0.02416816
p_int:  0.997668921
p_ni:  0.00214713
p_wrong:  0.000183949
Data Source:  BioPlex
TCEAL9
Tdark
Novelty:  0.3050647
p_int:  0.996741105
p_ni:  0.003254631
p_wrong:  0.000004264
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
97.4
testosterone measurement
4
4
4
91.8
low density lipoprotein cholesterol measurement
3
3
3
64.3
total cholesterol measurement
2
2
2
63.6
platelet crit
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
97.4
testosterone measurement
4
91.8
low density lipoprotein cholesterol measurement
3
64.3
total cholesterol measurement
2
63.6
platelet crit
1
61.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DIRAS family GTPase 1
VGNC:10997
744476
Mouse
MGI:2183442
208666
Rat
RGD:1310445
366826
Dog
DIRAS family GTPase 1
VGNC:39960
485068
Horse
DIRAS family GTPase 1
VGNC:17192
100060337
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DIRAS family GTPase 1
Mouse
Rat
Dog
DIRAS family GTPase 1
Horse
DIRAS family GTPase 1
Publication Statistics
PubMed Score 8.16
PubMed score by year
PubTator Score 16.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title