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Tdark
DIP2B
Disco-interacting protein 2 homolog B

Protein Summary
Description
This gene encodes a member of the disco-interacting protein homolog 2 protein family. The encoded protein contains a binding site for the transcriptional regulator DNA methyltransferase 1 associated protein 1 as well as AMP-binding sites. The presence of these sites suggests that the encoded protein may participate in DNA methylation. This gene is located near a folate-sensitive fragile site, and CGG-repeat expansion in the promoter of this gene which affects transcription has been detected in individuals containing this fragile site on chromosome 12. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301180
  • ENSP00000301180
  • ENSG00000066084

Symbol
  • KIAA1463
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
transcription factor
0.82
transcription factor binding site profile
0.81
microRNA
0.78
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 35   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 35   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999991687
p_ni:  0.000008313
Score:  0.181
Data Source:  BioPlex,STRINGDB
CNKSR3
Tbio
Family:  Enzyme
Novelty:  0.14999986
p_int:  0.999985152
p_ni:  0.000014848
Score:  0.826
Data Source:  BioPlex,STRINGDB
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.999943402
p_ni:  0.000056577
p_wrong:  2e-8
Score:  0.228
Data Source:  BioPlex,STRINGDB
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.999877027
p_ni:  0.000122918
p_wrong:  5.5e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.999567773
p_ni:  0.000427674
p_wrong:  0.000004553
Data Source:  BioPlex
SELE
Tchem
Novelty:  0.00029494
p_int:  0.99922482
p_ni:  0.000751605
p_wrong:  0.000023574
Score:  0.313
Data Source:  BioPlex,STRINGDB
CNK3/IPCEF1
Tbio
Novelty:  0.14999986
Score:  0.826
Data Source:  STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
Score:  0.8
Data Source:  STRINGDB
LARP4
Tbio
Novelty:  0.08499175
Score:  0.645
Data Source:  STRINGDB
C11orf53
Tdark
Novelty:  0.31246001
Score:  0.637
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
4
94.8
platelet crit
2
2
2
91.3
4
4
0
1.1
90.9
sex hormone-binding globulin measurement
6
2
6
85.7
balding measurement
2
2
2
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
94.8
platelet crit
2
91.3
0
1.1
90.9
sex hormone-binding globulin measurement
6
85.7
balding measurement
2
81.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
disco interacting protein 2 homolog B
VGNC:5357
451895
Macaque
disco interacting protein 2 homolog B
693515
Mouse
MGI:2145977
239667
Rat
RGD:1305671
300231
Dog
disco interacting protein 2 homolog B
VGNC:39959
477608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
disco interacting protein 2 homolog B
Macaque
disco interacting protein 2 homolog B
Mouse
Rat
Dog
disco interacting protein 2 homolog B
Publication Statistics
PubMed Score 10.00
PubMed score by year
PubTator Score 3.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title