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Tbio
DIEXF
Digestive organ expansion factor homolog

Protein Summary
Description
Regulates the p53 pathway to control the expansion growth of digestive organs.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000491415
  • ENSP00000419005
  • ENSG00000117597

Symbol
  • C1orf107
  • DEF
  • DEF
  • DIEXF
  • C1orf107
  • DJ434O14.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.92
transcription factor binding site profile
0.89
kinase perturbation
0.76
disease perturbation
0.74
histone modification site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.99   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.99   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999778
p_ni:  2.22e-7
Data Source:  BioPlex
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.999999209
p_ni:  7.91e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
PRPF31
Tbio
Novelty:  0.0105753
p_int:  0.999995017
p_ni:  0.000004983
Score:  0.408
Data Source:  BioPlex,STRINGDB
ARRB2
Tbio
Novelty:  0.00148149
p_int:  0.999961745
p_ni:  0.000036846
p_wrong:  0.000001408
Data Source:  BioPlex
PPAN
Tbio
Novelty:  0.01063709
p_int:  0.999886421
p_ni:  0.00011356
p_wrong:  1.9e-8
Score:  0.664
Data Source:  BioPlex,STRINGDB
AAK1
Tchem
Family:  Kinase
Novelty:  0.02438961
p_int:  0.999852794
p_ni:  0.000143843
p_wrong:  0.000003363
Data Source:  BioPlex
ZNF653
Tbio
Family:  TF
Novelty:  1.467544
p_int:  0.999834535
p_ni:  0.000165465
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.999737979
p_ni:  0.000261968
p_wrong:  5.3e-8
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.999635133
p_ni:  0.000364801
p_wrong:  6.6e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
IMP4
Tdark
Novelty:  9.64444444
p_int:  0.998637541
p_ni:  0.001362459
Score:  0.995
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

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Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
7
0
1.7
99.4
Cleft palate
4
5
0
1.5
98.4
Oral cleft
2
3
1
1.6
94.6
smoking status measurement
2
1
2
71.4
body mass index
2
2
2
64
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
99.4
Cleft palate
0
1.5
98.4
Oral cleft
1
1.6
94.6
smoking status measurement
2
71.4
body mass index
2
64
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 59.99
PubMed score by year
PubTator Score 161.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title