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Tbio
DIDO1
Death-inducer obliterator 1

Protein Summary
Description
Putative transcription factor, weakly pro-apoptotic when overexpressed (By similarity). Tumor suppressor. Required for early embryonic stem cell development. Isoform 2: Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes. Apoptosis, a major form of cell death, is an efficient mechanism for eliminating unwanted cells and is of central importance for development and homeostasis in metazoan animals. In mice, the death inducer-obliterator-1 gene is upregulated by apoptotic signals and encodes a cytoplasmic protein that translocates to the nucleus upon apoptotic signal activation. When overexpressed, the mouse protein induced apoptosis in cell lines growing in vitro. This gene is similar to the mouse gene and therefore is thought to be involved in apoptosis. Alternatively spliced transcripts have been found for this gene, encoding multiple isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266070
  • ENSP00000266070
  • ENSG00000101191
  • ENST00000354665
  • ENSP00000346692
  • ENST00000370366
  • ENSP00000359391
  • ENST00000370368
  • ENSP00000359394
  • ENST00000370371
  • ENSP00000359397
  • ENST00000395340
  • ENSP00000378749
  • ENST00000395343
  • ENSP00000378752

Symbol
  • C20orf158
  • DATF1
  • KIAA0333
  • BYE1
  • DIO1
  • DATF1
  • DIDO2
  • DIDO3
  • DIO-1
  • DATF-1
  • C20orf158
  • dJ885L7.8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
interacting protein
0.98
transcription factor perturbation
0.98
protein domain
0.97
drug perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.95   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.95   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0