Tbio DICER1 Endoribonuclease Dicer

Protein Summary

Description

Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9UPY3
• A7E2D3
• B3KRG4
• E0AD28
• O95943
• Q9UQ02

Gene Name

• DICER1

Ensembl ID

• ENST00000343455
• ENSP00000343745
• ENSG00000100697
• ENST00000393063
• ENSP00000376783
• ENST00000526495
• ENSP00000437256
• ENST00000527414
• ENSP00000435681
• ENST00000541352
• ENSP00000444719
• ENST00000556045
• ENSP00000451041

Symbol

• DICER
• HERNA
• KIAA0928
• DCR1
• GLOW
• MNG1
• Dicer
• HERNA
• RMSE2
• Dicer1e
• K12H4.8-LIKE

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
biological term	0.99
protein domain	0.97
microRNA	0.88

Protein Classes

PANTHER Classes

Protein / ... / Nuclease / Endodeoxyribonuclease / Endoribonuclease Dicer

Protein / ... / Dna Binding Protein / Endodeoxyribonuclease / Endoribonuclease Dicer

DTO Classes

Protein / Enzyme / Nuclease / Endodeoxyribonuclease / Endoribonuclease Dicer

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4102.89   (req: < 5)

Gene RIFs: 475   (req: <= 3)

Antibodies: 463   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4102.89   (req: >= 5)

Gene RIFs: 475   (req: > 3)

Antibodies: 463   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0